Pyrazoloadenine|2380-63-4|-陌孚医药/Medlife

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Pyrazoloadenine

目录号: PL10962

CAS No. :2380-63-4

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中文名称	Pyrazoloadenine
中文别名	4-氨基吡嗪[3,4-d]嘧啶;4-氨基吡唑[3,4-d]嘧啶;4-氨基吡唑并[3,4-d]嘧啶;4-Aminopyrazolo[3,4-d]pyrimidine 4-氨基吡唑并[3,4-d]嘧啶;4-氨基吡唑-1氢-[3,4-d]嘧啶;4-氨基吡唑并(3,4-d)嘧啶;4-氨基吡唑并嘧啶;1H-吡唑并[3,4-d]嘧啶-4-胺
英文名称	Pyrazoloadenine
英文别名	1H-Pyrazolo[3,4-d]pyrimidin-4-amine;4-amino-pyrazolo(3,4-D)pyrimidine;4-Aminopyrazolo[3,4-d]pyrimidine;4-Amino-1H-pyrazolo[3,4-d]pyrimidine;4-Amino-pyrazolo[3,4-d]pyrimidine;1H-pyrazolo[3,4-d]pyrimidin-4-ylamine;1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine 4-Amino-1H-pyrazolo[3,4-d]pyrimidine;4-aminopyrazolo-(3,4-d)pyrimidine;4-aminopyrazolo[5,4-d]pyrimidine;4-Aminopyrazolopyrimidine;4-app;7-deaza-8-aza-adenine;8-aza-7-deazaadenine;ADENINE ANTIMETABOLITE;Aminopurinol;Pyrazolo[3,4-d]pyrimidin-4-amin;pyrazolo[3,4-d]pyrimidin-4-amine;Pyrazoloadenine;1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine;4 APP;BP-12357;4-Aminopyrazolo(3,4-d)pyrimidine;4-aminopyrazolo[3,4-d] pyrimidine;W-200546;7-DEAZA-8-AZAADENINE;4-App;AKOS004910187;AB00505;EINECS 219-174-6;CS-D1726;2380-63-4;LS-129195;A814399;Z57101323;1H-Pyrazolo[3,4-d]pyrimidine, 4-amino-;64834-00-0;Pyrazolo(3,4-d)pyrimidin-4-amine;4-amino-1h-pyrazolo(3,4-d)pyrimidine;TS-00024;AC-8162;1H-pyrazolo[3, 4-d]pyrimidin-4-amine;NSC-1393;HY-34595;BRN 0005824;DTXSID3062362;NSC 1393;AT24508;Q27247530;1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YLAMINE;1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-YLAMINE;AM20090259;UNII-0356MAT9LX;2H-Pyrazolo[3,4-d]pyrimidin-4-amine;STK803066;4-Amino-1H-pyrazolo[3,4-D]pyrimidine;aminopurinol;1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-;BIDD:GT0454;2~{H}-pyrazolo[3,4-d]pyrimidin-4-amine;4-Aminopyrazolo[3,4-d]pyrimidine, 98%;SY007560;W-201772;A4965;AI3-52467;1H-Pyrazolo[3,4-d]pyrimidin-4-ylamine;TVW;FT-0740764;4-Aminopyrazole[3,4-d]pyrimidine;4-Aminopyrazole(3,4-d)pyrimidine;F9995-0069;FT-0617604;MFCD00005688;NSC1393;SCHEMBL11362;A1041;BBL002049;0356MAT9LX;4-Amino-1,2,5,7-tetraaza-1H-indene;EN300-91349;BDBM50208876;1H-Pyrazolo(3,4-d)pyrimidin-4-amine;BCP01216;SB12011;AB-323/25048512;CHEMBL388593;4APP-4;8-Aza-7-deazaadenine;1H-pyrazolo[3,4-d]pyrimidin-4-amine
Cas No.	2380-63-4
分子式	C₅H₅N₅
分子量	135.13
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	Pyrazoloadenine 是一种有效的 RET 肺癌癌蛋白抑制剂。Pyrazoloadenine 具有抗癌活性。
生物活性	Pyrazoloadenine is a potent RET (REarranged during Transfection) lung cancer oncoprotein inhibitor. Pyrazoloadenine shows anticancer activity.
性状	Solid
体外研究(In Vitro)	Pyrazoloadenine inhibits a wide range of protein kinases such as BTK (Bruton’s tyrosine kinase), CDK1/2 (cyclin-dependent kinase 1/2), Src kinase, and RIPK1 (receptor-interacting protein kinase). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Saha D, et al. Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach. ChemMedChem. 2021 May 18;16(10):1605-1608. [2]. SKIPPER HE, et al. Inhibition of experimental neoplasms by 4-aminopyrazolo (3, 4-d) pyrimidine. Proc Soc Exp Biol Med. 1955 Aug;89(4):594-6.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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