Protease-Activated Receptor-2, amide|190383-13-2|(蛋白酶活化的受体-2，酰胺)-陌孚医药/Medlife

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Protease-Activated Receptor-2, amide (Synonyms: 蛋白酶活化的受体-2，酰胺)

目录号: PL10704 纯度: ≥99%

CAS No. :190383-13-2

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中文名称	Protease-Activated Receptor-2, amide
中文别名	2,6-二氟苯腈;H-丝氨酰亮氨酰异亮氨酰甘氨酰赖氨酰缬氨酰NH2
英文名称	Protease-Activated Receptor-2, amide
英文别名	L-Valinamide,L-seryl-L-leucyl-L-isoleucylglycyl-L-lysyl-;H-Ser-Leu-Ile-Gly-Lys-Val-NH2;PAR-2 (1-6) amide (human);Ser-Leu-Ile-Gly-Lys-Val-amide;SLIGKV-NH2;(2S)-6-amino-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]hexanamide;PAR-2 (1-6) Human;PAR2 activating peptide;PAR2-AP;Par-2 Ago;SLIGKVAMIDE;PAR-2 AGONIST AMIDE;SER-LEU-ILE-GLY-LYS-VAL-NH2;PAR-2 AGONIST PEPTIDE (SLIGKV) AMIDE, HUMAN;Protease-Activated Receptor-2, amide
Cas No.	190383-13-2
分子式	C₂₈H₅₄N₈O₇
分子量	614.78
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Protease-Activated Receptor-2, amide (SLIGKV-NH₂) 是一种高效的蛋白酶活化受体-2 (PAR2) 活化肽。
生物活性	Protease-Activated Receptor-2, amide (SLIGKV-NH 2 ) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.
性状	Solid
IC50 & Target[1][2]	PAR2
体外研究(In Vitro)	The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH2, SLIGRL-NH2. The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH2) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH2) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	SLIGKV-NH2
Sequence	Ser-Leu-Ile-Gly-Lys-Val-NH2
参考文献	[1]. Kanke T, et al. Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Br J Pharmacol. 2005 May;145(2):255-63. [2]. Ramelli G, et al. Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cellactivation in vivo. Immunology. 2010 Jan;129(1):20-7.

溶解度数据	In Vitro: H₂O : 33.33 mg/mL (54.21 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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