Boc-Hyp-OH
目录号: PL10533
CAS No. :13726-69-7
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中文名称
Boc-Hyp-OH
中文别名
BOC-L-羟脯氨酸;N-Boc-反式-4-羟基-L-脯氨酸;N-BOC-L-羟脯氨酸;反-N-(叔丁氧羰基)-4-羟基-L-脯氨酸;3-羟基-1-甲基四氢吡咯;BOC-L-羟基脯氨酸;trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline 反-N-(叔丁氧羰基)-4-羟基-L-脯氨酸;BOC-4-羟基-L-脯氨酸;N-叔丁氧羰基-4-羟基-L-脯氨酸;反-N-Boc-4-羟基-L-脯氨酸;叔丁氧羰酰基-反式-4-羟基-L-脯氨酸;叔丁氧羰酰基羟脯氨酸;反-N-(叔丁氧基羰基)-4-羟基-L-脯氨酸;BOC-羟脯氨酸;BOC-L-羟脯氨;BOC-L-羟脯胺酸;BOC-L-羟脯氨酸,98%;BOC-L-羟脯氨酸 1KG
英文名称
Boc-Hyp-OH
英文别名
(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;N-BOC-trans-4-hydroxy-L-proline;N-T-bocl-hydroxyproline;Boc-L-Hyp-OHN-(tert-Butoxycarbonyl)-L-4-hydroxyproline;(2S,4R)-1-(tertbutoxycarbonyl)-4-hydroxypyrrolidine carboxylic acid;Boc-L-Hydroxyproline;trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;Boc-Hyp-OH;(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;Boc-Hyp;BOC-L-Hyp-OH;Boc-O-Hyp-OH;Boc-trans-4-hydroxy-L-proline;Boc-trans-Hydroxy-L-proline;BOC-HYDROXYPROLINE;BOC-L-4-HYDROXYPROLINE;BOC-TRANS-HYP-OH;N-BOC-L-Hydroxyproline;N-ter;RARECHEM EM WB 0136;trans-Boc-Hyp-OH;trans-N-Boc-4-hydroxy-L-proline;Teneint-E;Boc-Hyp-OH, >=98.0%
Cas No.
13726-69-7
分子式
C10H17NO5
分子量
231.25
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
Boc-Hyp-OH 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。Boc-Hyp-OH 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。
生物活性
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
性状
Solid
IC50 & Target[1][2]
Non-cleavable
体外研究(In Vitro)
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
溶解度数据
In Vitro: DMSO : ≥ 100 mg/mL (432.43 mM)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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