Azido-PEG7-amine
目录号: PL10536 纯度: ≥95.0%
CAS No. :1333154-77-0
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中文名称
Azido-PEG7-amine
中文别名
氨基-七聚乙二醇-叠氮
英文名称
Azido-PEG7-amine
英文别名
Amino-PEG8-azide;NH2-PEG8-N3;Azido-PEG7-amine;N3-PEG7-CH2CH2NH2;Amino-PEG7-azide;Azido-dPEG?7-amine;Azido-dPEG(R)7-amine;BIPG1130;BIPG1885;VZKXLNRXAFTBOW-UHFFFAOYSA-N
Cas No.
1333154-77-0
分子式
C16H34N4O7
分子量
394.46
包装储存
-20°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
产品详情
Azido-PEG7-amine 是一种不可降解 (non-cleavable) 的 7 单元 PEG-ADC 连接物,用于抗体偶联药物 (ADC) 的合成。Azido-PEG7-amine 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
生物活性
Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
性状
Liquid
IC50 & Target[1][2]
Non-cleavable PEGs
体外研究(In Vitro)
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献
[1]. Kevin W. Gillman, et al. Macrocyclic peptides useful as immunomodulators. WO2016077518A1.
溶解度数据
In Vitro: DMSO : 100 mg/mL (253.51 mM; Need ultrasonic)H2O : 100 mg/mL (253.51 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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