NH2-PEG2-C2-Boc
目录号: PL10529 纯度: ≥98.0%
CAS No. :756525-95-8
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中文名称
NH2-PEG2-C2-Boc
中文别名
氨基-聚乙二醇-丙酸叔丁酯;3-[2-(2-氨基乙氧基)乙氧基]丙酸叔丁酯;9-氨基-4,7-二氧杂壬酸叔丁酯;氨基二聚乙二醇缬氨酸叔丁酯
英文名称
NH2-PEG2-C2-Boc
英文别名
Amino-PEG2-t-butyl ester;tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate;3-[2-(2-Aminoethoxy)ethoxy]propanoic acid 1,1-dimethylethyl ester;H2N-PEG2-tBu;SDZ-P2-NH2;tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate;tert-butyl 9-AMino-4,7-dioxanonanoate;H2N-PEG2-CH2CH2COOtBu;H2N-PEG2-CO-OtBu;H2N-EG2-CO-OTBU;BIPG1044;XIVHGTLMLORWEP-UHFFFAOYSA-N;NH2-PEG2-CH2CH2-t-butyl ester;KM1704;SY122493;AK307937;AX8225908;NH2-PEG2-C2-Boc
Cas No.
756525-95-8
分子式
C11H23NO4
分子量
233.30
包装储存
Pure form -20°C 3 years;4°C 2 years
产品详情
NH2-PEG2-C2-Boc 是一种 PROTAC linker,属于 PEG 类。NH2-PEG2-C2-Boc 可用于合成PROTAC分子。NH2-PEG2-C2-Boc 也是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
生物活性
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
性状
Liquid
IC50 & Target[1][2]
PEGs Alkyl/ether
体外研究(In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years;4°C 2 years
参考文献
[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964.
[2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.
溶解度数据
In Vitro: DMSO : ≥ 100 mg/mL (428.63 mM)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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