Boc-Hyp-OMe|74844-91-0|-陌孚医药/Medlife

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Boc-Hyp-OMe

目录号: PL10497 纯度: ≥97.0%

CAS No. :74844-91-0

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中文名称	Boc-Hyp-OMe
中文别名	N-BOC-反式-4-羟基-L-脯氨酸甲酯;N-叔丁氧羰基-反式-4-羟基-L-脯氨酸甲酯;BOC-L-羟脯氨酸甲酯;N-(叔丁氧羰基)-反-4-羟基-L-脯氨酸甲酯;(2S,4R)-4-羟基吡咯烷-N-Boc-2-羧酸甲酯;Boc-L-苯甘氨酸;BOC-L-羟基脯氨酸;BOC-反式-4-羟基-L-脯氨酸甲酯;Boc-羟脯氨酸甲酯;N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-proline Methyl Ester N-(叔丁氧羰基)-反-4-羟基-L-脯氨酸甲酯;N-BOC-L-羟脯氨酸甲酯;N-Boc-反式-4-羟基-L-脯氨酸甲酯及合成技术;(2S,4R)-N-Boc-4-羟基-2-吡咯啉甲酸甲酯;N-Boc-反式-4-羟基-L-脯氨酸甲酯,N-叔丁氧羰基-反式-4-羟基-L-脯氨酸甲酯;N-BOC-L-羟基脯氨酸甲酯;N-Boc-反式-4-羟基-L-脯氨酸甲酯
英文名称	Boc-Hyp-OMe
英文别名	Boc-Hyp-OMe;N-BOC-trans-4-hydroxy-L-proline methyl ester;(2S,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-L-hydroxyproline methyl ester;N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-proline Methyl Ester;(2S,4R)-1-BOC-4-HYDROXY-PROLINE METHYL ESTER;(2S,4R)-1-tert-Butyl 2-methyl-4-hydroxypyrrolidine-1,2-dicarboxylate;(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester;(2S,4R)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate;1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-O-Hyp-OMe;BOC-HYDROXYPROLINE-OME;BOC-L-4-HYDROXYPROLINE METHYL ESTER;BOC-L-T-4-HYDROXYPROLINE METHYL ESTER;Boc-trans-4-hydroxy-L-proline methyl ester;N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER;N-BOC-L-Hydroxyproline methyl ester;N-Boc-trans-hydro-L-prolinemethylester;N-BOC-transydro-L-prolinemethylester;(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester;N-(tert-Butoxycarbonyl)-trans-hydroxy-L-proline methyl ester;trans-1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline methyl ester;O1-TERT-BUTYL O2-METHYL (2S,4R)-4-HYDROXYPYRROLI;N-Boc-trans-4-hydroxy-L-proline Methyl Ester;1-tert-Butyl 2-Methyl (2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylate
Cas No.	74844-91-0
分子式	C₁₁H₁₉NO₅
分子量	245.27
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Boc-Hyp-OMe 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。Boc-Hyp-OMe 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性	Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
性状	Solid
IC50 & Target[1][2]	Non-cleavable
体外研究(In Vitro)	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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