NH2-PEG4-CH2CH2COOH (Synonyms: 1-氨基-3,6,9,12-四氧代十五烷-15-酸)
目录号: PL10513 纯度: ≥98.0%
CAS No. :663921-15-1
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中文名称
NH2-PEG4-CH2CH2COOH
中文别名
3-[2-[2-[2-(2-氨基乙氧基)乙氧基]乙氧基]乙氧基]丙酸;氨基四聚乙二醇羧乙基
英文名称
NH2-PEG4-CH2CH2COOH
英文别名
1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid;alpha-aMine-oMega-propionic acid tetraethylene glycol;H2N-PEG4-CH2CH2COOH;α-Amine-ω-propionic acid tetraethylene glycol;(PEO)4-amino-propionic acid;3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid;-AMINE-?-PROPIONIC ACID TETRAETHYLENE GLYCOL;Amino-PEG4-propionic acid;H2N-dPEG4-COOH;AmbotzPEG1370;Amino-PEG4-acid;H2N-DPEG(4)-COOH;3-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)propanoic acid;(PEO)4-Aminopropionic acid;BIPG1033;C11H23NO6;DKUZHSD;NH2-PEG4-CH2CH2COOH
Cas No.
663921-15-1
分子式
C11H23NO6
分子量
265.30
包装储存
-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
产品详情
NH2-PEG4-CH2CH2COOH 是一种可降解 (cleavable) 的 4 单元 PEG 类 ADC linker,用于抗体偶联药物 (ADC) 的合成。NH2-PEG4-CH2CH2COOH 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
生物活性
NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
性状
Solid-liquid mixture
IC50 & Target[1][2]
Cleavable PEGs
体外研究(In Vitro)
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献
[1]. Hans-Georg Lerchen, et al. Antibody drug conjugates (adcs) having enzymatically cleavable groups. WO2018114578A1.
溶解度数据
In Vitro: DMSO : 10 mg/mL (37.69 mM; ultrasonic and warming and heat to 60°C)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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