H-Hyp-OMe hydrochloride|40216-83-9|-陌孚医药/Medlife

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H-Hyp-OMe hydrochloride

目录号: PL10508 纯度: ≥97.0%

CAS No. :40216-83-9

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中文名称	H-Hyp-OMe hydrochloride
中文别名	反式-4-羟基-L-脯氨酸甲酯盐酸盐;L-羟脯氨酸甲酯盐酸盐;(2S,4R)-4-羟基-L-脯氨酸甲酯;羟脯氨酸甲酯盐酸盐;(1-壬基)三苯基溴化磷;5-溴-2-甲氧基苯甲醇;L-4-羟脯氨酸甲酯盐酸盐;L-4-羟脯氨酸甲酯盐酸盐,L-4-Hydroxyproline methyl ester;trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride 反式-4-羟基-L-脯氨酸甲酯盐酸盐;反式-4-羟基-L-脯氨酸甲酯盐酸盐及合成技术;L-4-羟基脯氨酸甲酯盐酸盐;L-羟脯氨酸甲酯盐酸;反-4-羟基-L-脯氨酸甲酯盐酸盐;(2S,4R)-4-羟基吡咯烷-2-甲酸甲酯盐酸盐
英文名称	H-Hyp-OMe hydrochloride
英文别名	(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;trans-4-Hydroxy-L-proline methyl ester;4-HYDROXY-L-PROLINE METHYL ESTER HCl;H-HYP-OME HCL;H-L-HYP-OME HCL;HYDROXYPROLINE-OME HCL;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride;trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride;H-Hyp-OMe·HCl;Hydroxyproline methyl ester hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;H-Hyp-Ome.HCL;H-O-Hyp-OMe·HCl;L-4-Hydroxyproline methyl ester;Trans-4-Hydroxy-L-Proline Methyl Ester, Hydrochloride Salt;(2S,4R)-2-methoxycarbonyl-4-hydroxypyrrolidine hydrochloride;(2S,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride;(2S,4R)-4-hydroxy-L-proline methyl ester;(2S,4R)-4-Hydroxy-pyrrolidine-2-car;Hyp-Ome HCL;L-HYDROXYPROLINE METHYL ESTER HCL;methyl (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylate hydrochloride;Methyl L-Hydroxyprolinate Hydrochloride;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride;L-Proline,4-hydroxy-, methyl ester, hydrochloride, (4R)- (9CI);L-Proline, 4-hydroxy-, methylester, hydrochloride, trans-;Proline, 4-hydroxy-, methyl ester, hydrochloride(7CI);(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl esterhydrochloride;(4R)-4-Hydroxy-L-proline methyl ester hydrochloride;4-Hydroxy-L-proline methylester hydrochloride;4-Hydroxyproline methyl ester hydrochloride;4-trans-Hydroxy-L-proline methyl ester hydrochloride;L-Hydroxyproline methyl ester hydrochloride;Methyl trans-4-hydroxy-L-prolinatehydrochloride;Hydroxyproline methylester hydrochloride;Methyl(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylate hydrochloride;MethylL-hydroxyprolinate hydrochloride;Methyl (2S,4R)-4-Hydroxypyrrolidine-2-carboxylate Hydrochloride;H-Hyp-OMe hydrochloride
Cas No.	40216-83-9
分子式	C₆H₁₁NO₃^.HCl
分子量	181.62
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	H-Hyp-OMe (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。H-Hyp-OMe (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性	H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
性状	Solid
IC50 & Target[1][2]	Non-cleavable
体外研究(In Vitro)	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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