Maleimido-tri(ethylene glycol)-propionic acid
目录号: PL10494 纯度: ≥99%
CAS No. :518044-40-1
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中文名称
Maleimido-tri(ethylene glycol)-propionic acid
中文别名
马来酰亚胺-三(乙烯乙二醇)-丙酸
英文名称
Maleimido-tri(ethylene glycol)-propionic acid
英文别名
Propanoic acid,3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-;3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid;MALEIMIDO-TRI(ETHYLENE GLYCOL)-PROPIONIC ACID;3-(2-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)ethoxy)propanoic acid;A18830;FT-0604026;PubChem11737;Maleimido-tri(ethylene glycol)-propionic acid
Cas No.
518044-40-1
分子式
C13H19NO7
分子量
301.29
包装储存
Pure form -20°C 3 years;4°C 2 years
产品详情
Maleimido-tri(ethylene glycol)-propionic acid 是一种可降解 (cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。Maleimido-tri(ethylene glycol)-propionic acid 用于 neolymphostin 为基础的 ADC 前体的制备,用于位点特异性半胱氨酸突变体曲妥珠单抗- A114C 的偶联。Maleimido-tri(ethylene glycol)-propionic acid 也可以用作基于 PEG 的 PROTAC Linker,可用于合成PROTAC。
生物活性
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
性状
Liquid
IC50 & Target[1][2]
Cleavable PEGs
体外研究(In Vitro)
Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7.
ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively.
ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively.
ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years;4°C 2 years
参考文献
[1]. Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.
溶解度数据
In Vitro: DMSO : 100 mg/mL (331.91 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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