kb NB 142-70|1233533-04-4|-陌孚医药/Medlife

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kb NB 142-70

目录号: PL09910 纯度: ≥98%

CAS No. :1233533-04-4

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中文名称	kb NB 142-70
中文别名	3,4-二氢-9-羟基-[1]苯并噻吩并[2,3-f]-1,4-硫氮杂革-5(2H)-酮;3,4-二氢-9-羟基-[1]苯并噻吩并[2,3-F]-1,4-硫氮杂卓-5(2H)-酮;kb NB 142-70
英文名称	kb NB 142-70
英文别名	kb-NB142-70;3,4-Dihydro-9-hydroxy-[1]benzothieno-[2,3-f]-1,4-thiazepin-5(2H)-one;3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;kb NB 142-70;AG-L-65866;CHEBI:1169969;CHEMBL1672571;CS-1091;CTK8G0429;QCR-15;SureCN9920595;9-hydroxy-3,4-dihydro-2H-[1]benzothiolo[2,3-f][1,4]thiazepin-5-one;DHUAGGSHTKPOHU-UHFFFAOYSA-N;GTPL9369;AOB1401;SYN5189;HMS3740G15;BCP06729;BDBM50336960;3758AH;AB0094895;kb-
Cas No.	1233533-04-4
分子式	C₁₁H₉NO₂S₂
分子量	251.32
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	kb NB 142-70 是一种有效的 PKD 抑制剂，对 PKD1，PKD2 和 PKD3 的 IC₅₀ 值分别为 28.3 nM，58.7 nM 和 53.2 nM；kb NB 142-70 同时具有抗肿瘤活性。
生物活性	kb NB 142-70 is a potent PKD inhibitor, with IC 50 s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.
性状	Solid
IC50 & Target[1][2]	PKD1 28.3 nM (IC50) PKD3 53.2 nM (IC5
体外研究(In Vitro)	kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser and Ser, HDAC5 at Ser and Ser, and HDAC7 at Ser in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12,13-dibutyrate (PDBu). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Lavalle CR, et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 2010 May 5;10:5. [2]. James Sinnett-Smith, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306(10): C961-C971.

溶解度数据	In Vitro: DMSO : 46.67 mg/mL (185.70 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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