Porcn-IN-1|2036044-77-4|-陌孚医药/Medlife

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Porcn-IN-1

目录号: PL09920 纯度: ≥99%

CAS No. :2036044-77-4

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中文名称	Porcn-IN-1
中文别名	N-((3-氟-2'-甲基-[2，4'-联吡啶]-5-基)甲基)-9H-咔唑-2-甲酰胺
英文名称	Porcn-IN-1
英文别名	Porcn-IN-1;Porcupine-IN-1;BCP30141;BDBM50197277;AK00779576;J3.568.978H;N-((3-fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide;N-((3-Fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide;N-((3-Fluoro-2a?methyl[2,4a?bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide;N-(3-Fluoro-2'-methyl-2,4'-bipyridine-5-ylmethyl)-9H-carbazole-2-carboxamide
Cas No.	2036044-77-4
分子式	C₂₅H₁₉FN₄O
分子量	410.44
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Porcn-IN-1 是有效的 porcupine 抑制剂，IC₅₀ 值为 0.5±0.2 nM。
生物活性	Porcn-IN-1 is potent porcupine inhibitor with an IC 50 of 0.5±0.2 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 0.5±0.2 nM (Porcupine inhibitor)
体外研究(In Vitro)	Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Xu Z, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the reversed amide scaffold.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (243.64 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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