Bucladesine calcium|938448-87-4|(二丁酰环磷腺苷钙; Dibutyryl cAMP calcium salt; DBcAMP calcium salt)-陌孚医药/Medlife

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Bucladesine calcium (Synonyms: 二丁酰环磷腺苷钙; Dibutyryl cAMP calcium salt; DBcAMP calcium salt)

目录号: PL09717 纯度: ≥99%

CAS No. :938448-87-4

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中文名称	Bucladesine calcium
中文别名	二丁酰环磷腺苷钙;N-(1-氧代丁基)-腺苷环 3',5'-(磷酸氢酯) 2'-丁酸酯钙盐 (2:1);Bucladesine (calcium salt)
英文名称	Bucladesine calcium
英文别名	Bucladesine calcium;Bucladesine (calciuM salt);DC2797 calcium salt;Dibutyryl-cAMP calcium salt;[(4Ar,6R,7R,7aR)-6-[6-(butanoylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d];Dibutyryl cAMP calcium salt;DBcAMP calcium salt;Calcium N6-2′-O-dibutyryl cyclic adenosine-3′,5′-monophosphate
Cas No.	938448-87-4
分子式	C₁₈H₂₄CaN₅O₈P
分子量	509.46
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) 是可渗透细胞的 cAMP 类似物，可通过增加细胞内 cAMP 水平，选择性激活 cAMP 依赖性蛋白激酶(PKA)。Bucladesine calcium salt 也有磷酸二酯酶 (PDE) 抑制剂的作用。
生物活性	Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.
性状	Solid
IC50 & Target[1][2]	PKA PDE
体内研究(In Vivo)	Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats. Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine. Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20. [2]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.

溶解度数据	In Vitro: H₂O : 100 mg/mL (204.74 mM; Need ultrasonic)DMSO : ≥ 100 mg/mL (204.74 mM)

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