Amiodarone hydrochloride|19774-82-4|-陌孚医药/Medlife

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Amiodarone hydrochloride

目录号: PL10031 纯度: ≥99%

CAS No. :19774-82-4

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中文名称	Amiodarone hydrochloride
中文别名	盐酸胺碘酮;2-丁基-3-苯并呋喃基-4-[2-(二乙氨基)乙氧基]-3,5-二碘苯基甲酮盐酸盐;胺碘酮盐酸盐;盐酸胺磺酮;2-(2-氯乙酰氨基)-4-噻唑乙酸乙酯;2,6-二(三氟甲基)喹啉-4-甲酸乙酯;Amiodarone HCl 盐酸胺碘酮标准品;Amiodarone Hydrochloride 胺碘酮盐酸盐;胺碘酮-D4盐酸;盐酸氨丙啉;盐酸胺碘酮 EP标准品;盐酸胺碘酮 USP标准品;盐酸胺碘酮标准品;盐酸胺碘酮,BP2000 & EP4.01;盐酸胺碘酮Amiodarone hydrochloride;盐酸胺碘酮及其杂质;盐酸去乙胺碘酮杂质;盐酸乙胺碘呋酮;乙胺碘呋酮盐酸盐;盐酸胺碘酮D4;盐酸胺碘酮杂质;盐酸胺碘酮(标准品);AMIODARONE HCL 盐酸胺碘酮;胺碘酮盐酸盐(USP美国药典标准品);盐酸胺碘酮(CAS号:19774-82-4);盐酸胺碘酮/乙胺碘呋酮
英文名称	Amiodarone hydrochloride
英文别名	Amiodarone HCL;Amiodarone hydrochloride;(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone hydrochloride;Amiodarone (hydrochloride);Amiodarone hydrochloride solution;AMIODARONUM HYDROCHLORIDE;(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone,hydrochloride;(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride;2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride;[ "" ];l3428;cordarone;trangorex;skf33134a;Nexterone;l3428labaz;AMidorone (HCl);AMiodrone Hcl BP;AMIODARONE-D4 HCL;Amiodar;Pacerone;Ritmocardyl;Rythmarone;Renodoron;Angoron;Miodrone;Atlansil;51087 N HCl;MLS000028520;L 3428 labaz;976728SY6Z;SMR000058296;CPD000058296;SKF 33134-A;SKF 33134 A;DSSTox_RID_79304;DSSTox_CID_17185;DSSTox_G;2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;(2-BUTYL-3-BENZOFURANYL)-[4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODO-PHENYL]-METHANONE HYDROCHLORIDE;AMIODARONE HCL;AMIODARONE HYDROCHLORIDE;2-butyl-3-benzofuryl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride;AMIODARONEHCL(2-BUTYL-3-BENZOFURANYL-4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYLKETONE)
Cas No.	19774-82-4
分子式	C₂₅H₃₀Cli₂NO₃
分子量	681.77
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Amiodarone hydrochloride是一种 III 类抗心律失常剂，可抑制野生型IhERG 钾通道及其尾电流，IC₅₀ 约为 45 nM。Amiodarone hydrochloride通过成纤维细胞中，Amiodarone hydrochloride ERK1/2 和p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化。Amiodarone hydrochloride可用于室上性和室性心律失常的研究。

生物活性

Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC 50 of ～45 nM. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias.

性状

Solid

体外研究(In Vitro)

Amiodarone blocks inward IhERG tails in a high K external solution ([K]e) of 94 mM with an IC50 of 117.8 nM.
Amiodarone (1 μM) blocks inwardIhERG by 68.8±6.1%, with concentration response data yielding IC50 and h values of 765.5±287.8 nM and 0.9±0.4 for T623A hERG.
Amiodarone (1 μM) blocks inward IhERG with an IC50 and h values of 979.2±84.3 nM and 1.1±0.1 for S624A hERG.
Amiodarone (1-6?μg/mL) induces human embryonic lung fibroblasts (HELFs) cell proliferation and PD98059 or SB203580 suppresses this effect.
Amiodarone (1-6?ug/mL) does not induces HELFs cell apoptosis. Amiodarone (over 15?ug/mL) induces cell apoptosis.
Amiodarone (1, 3 and 6?μg/mL;24?hours) induces α-SMA and vimentin mRNA and protein expression accompanied by increased phosphorylation of ERK1/2 and p38 MAPK.

体内研究(In Vivo)

Long-term Amiodarone (90, and 180 mg/kg/day) treatment induces a dose-dependent remodeling of ion-channel expression that is correlated with the cardiac electrophysiologic effects of Amiodarone. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Yihong Zhang,et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35.
[2]. Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889.

溶解度数据	In Vitro: DMSO : 24.5 mg/mL (35.94 mM; Need ultrasonic and warming)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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