PI-273|925069-34-7|-陌孚医药/Medlife

您当前的位置：

PI-273

目录号: PL09836 纯度: ≥98.0%

CAS No. :925069-34-7

商品编号	规格	价格	会员价
PL09836-1mg	1mg	¥989.09	请登录
PL09836-5mg	5mg	¥1978.18	请登录
PL09836-10mg	10mg	¥3338.18	请登录
PL09836-25mg	25mg	¥6800.00	请登录
PL09836-50mg	50mg	¥11127.27	请登录
PL09836-100mg	100mg	¥18545.45	请登录
PL09836-200mg	200mg	询价	询价
PL09836-500mg	500mg	询价	询价
PL09836-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4155.42	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	PI-273
中文别名	2-(3-(4-氯苯甲酰基)硫脲基)-4-乙基-5-甲基噻吩-3-甲酰胺
英文名称	PI-273
英文别名	ARONIS023355;STK355951;BB0293001;2-({[(4-chlorobenzoyl)amino]carbonothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide;2-({[(4-chlorophenyl)carbonyl]carbamothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide;2-({[(4-chlorobenzoyl)amino]carbothioyl}amino)-4-ethyl-5-methyl-3-thiophenecarboxamide;2-({[(4-chlorobenzoyl)amino]carbonothioyl}amino)-4-ethyl-5-methyl-3-thiophenecarboxamide;PI-273;2-[[[(4-Chlorobenzoyl)amino]thioxomethyl]amino]-4-ethyl-5-methyl-3-thiophenecarboxamide (ACI);2-[(4-Chlorobenzoyl)carbamothioylamino]-4-ethyl-5-methylthiophene-3-carboxamide;2-[3-(4-Chloro-benzoyl)-thioureido]-4-ethyl-5-methyl-thiophene-3-carboxylic acid amide;PI 273
Cas No.	925069-34-7
分子式	C₁₆H₁₆ClN₃O₂S₂
分子量	381.90
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	PI-273 是第一种可逆的和特异性磷脂酰肌醇 4-激酶 (PI4KIIα) 抑制剂，IC₅₀ 为 0.47 μM。PI-273 可以抑制乳腺癌细胞的增殖，阻断细胞周期并诱导细胞凋亡。
生物活性	PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC 50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
性状	Solid
IC50 & Target[1][2]	PI4KIIα 0.47 μM (IC50)
体外研究(In Vitro)	PI-273 (2 μM; 48 hours) blocks the cell cycle at the G2-M phase. PI-273 (2 μM; 48 hours) induces cell apoptosis in all three Ras wild-type breast cancer cells: MCF-7, T-47D, and SK-BR-3. PI-273 (0.5-2 μM; for 3 days) can suppress the AKT signaling pathway in a dose- and time-dependent manner. PI-273 of 1 μM and 2 μM inhibits the cell proliferation of both MCF-7 and T-47D cells in a time-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	PI-273 (intraperitoneal injection; 25 mg/kg/day; 15 days) profoundly suppresses the tumor volume and weight in the MCF-7 xenografts. PI-273 (0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically); 0.08-5 hours) has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266.

溶解度数据	In Vitro: DMSO : 6.02 mg/mL (15.76 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation