FH535|108409-83-2|-陌孚医药/Medlife

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FH535

目录号: PL10052 纯度: ≥99%

CAS No. :108409-83-2

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中文名称	FH535
中文别名	2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺;4-氨基-2-氯烟醛三氟乙酸盐;EDTA 镁二钾盐;FH535 抑制剂;N-(2-甲基-4-硝基苯基)-2,5-二氯苯磺酰胺;正辛醛-d16;FH535, 一种WNT;Β-CATENIN和PPAR信号传导抑制剂
英文名称	FH535
英文别名	N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide;FH535;2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide;FH-535;FH 535(FH-535);2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535;Tcf Inhibitor, FH535;β-Catenin;β-catenin and PPAR
Cas No.	108409-83-2
分子式	C₁₃H₁₀N₂O₄Scl₂
分子量	361.20
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	FH535 是 Wnt/β-catenin 和 PPAR 的抑制剂，具有抗肿瘤活性。
生物活性	FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
性状	Solid
IC50 & Target[1][2]	PPAR β-catenin
体外研究(In Vitro)	FH535 is an inhibitor of Wnt/β-catenin and PPAR. FH535 inhibits PPARγ and PPARδ transactivation in HCT116 cells. FH535 (15 μM) activities depend on functional PPARδ but does not require a cysteine residue in the PPAR ligand-binding domain. FH535 inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows toxic effects on 12 carcinoma cell lines expressing wnt/β-catenin pathway. FH535 (20 μM) suppresses the β-catenin pathway in pancreatic cancer cells, and inhibits pancreatic cancer cell migration. Furthermore, FH535 (20, 40 μM) inhibits pancreatic cancer cell invasion and cell growth. FH535 represses angiogenesis-related genes in pancreatic cancer cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Handeli S, et al. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther. 2008 Mar;7(3):521-9. [2]. Wu MY, et al. FH535 inhibited metastasis and growth of pancreatic cancer cells. Onco Targets Ther. 2015 Jul 6;8:1651-70. [3]. Liu L, et al. FH5

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (92.28 mM; Need ultrasonic)配制储备液

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