LYP-IN-1 是一种有效、选择性和特异性的 LYP 抑制剂，其 K_i，IC₅₀ 的值分别为 110 nM 和 0.259 μM。LYP-IN-1 对一些 PTPs 也有选择性，如 SHP1 (IC₅₀=5 μM) 和 SHP2 (IC₅₀=2.5 μM)。LYP-IN-1 在 T 细胞和肥大细胞中表现出高效的细胞活性。LYP-IN-1 可用于研究自身免疫性疾病。

LYP-IN-1 is a potent, selective and specific LYP inhibitor with a K i and an IC 50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC 50 =5 μM) and SHP2 (IC 50 =2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders.

Solid

IC50: 0.259 μM (LYP)
Ki: 110 nM (LYP)

LYP-IN-1 has inhibitory activity toward a panel of mammalian PTPs including SHP1, SHP2, PTP-Meg2, FAP1 and PTP-PEST, with IC50 values of 5 μM, 2.5 μM, 0.59 μM, 0.39 μM, and 0.8 μM, respectively.
LYP-IN-1 (15 μM) increases both basal and TCR-stimulated phosphorylation of ZAP-70 on Tyr319 in JTAg cells.
LYP-IN-1 (15 μM) treatment of mouse thymocytes effectively causes an increase in the activation of double-positive (DP) thymocytes, it increased surface expression of CD69 (a marker of T cell activation) and Nur77.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated With Autoimmune Diseases