Norethindrone acetate|51-98-9|(醋酸炔诺酮; 19-Norethindrone acetate)-陌孚医药/Medlife

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Norethindrone acetate (Synonyms: 醋酸炔诺酮; 19-Norethindrone acetate)

目录号: PL10074 纯度: ≥99%

CAS No. :51-98-9

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中文名称	Norethindrone acetate
中文别名	醋酸炔诺酮;炔诺酮乙酸酯;19-炔诺酮醋酸酯标准品;1-氯-3,5-二甲基金刚烷;Norethisterone Acetate 醋酸炔诺酮;醋酸炔诺酮标准品;醋酸炔诺酮(甾体);炔诺酮醋酸盐标准品;炔诺酮醋酸酯;炔诺酮醋酸酯 USP标准品;17Α-乙炔基-17Β-羟基雌甾-4-烯-3-酮17-醋酸酯;17α-乙炔基-19-去甲睾酮乙酸酯;17Α-乙炔基雌甾-4-烯-17Β-醇-3-酮17-醋酸酯;17β-羟基9-去甲-17α-孕甾-4-烯-20-炔-3-酮-17-醋酸酯;17Β-乙酰氧基-17Α-乙炔基雌甾-4-烯-3-酮;17α-乙炔基-17β-羟基-19-去甲-4-雄甾烯-3-酮 17-乙酸酯;17α-乙炔基-19-去甲睾酮 17β-乙酸酯;17-羟基-19-去甲-17α-孕甾-4-烯-20-炔基-3-酮乙酸酯;去甲基脱氢羟孕酮 17-乙酸酯;19-去甲-17α-乙炔基睾酮乙酸酯
英文名称	Norethindrone acetate
英文别名	norethindrone acetate;17Alpha-Ethynyl-19-Nortestosterone Acetate;Norethisterone Acetate;[(8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate;19-Norethindrone acetate;Norethindrone Acetat;NORETHINDRONE ACETATE CRYSTALLINE;17α-Ethynyl-19-nortestosterone Acetate;19-Nor-17α-ethynyltestosterone Acetate;17a-Ethynyl-19-nortestosterone 17b-acetate;17-Hydroxy-19-nor-17a-4-pregnen-20-yn-3-one acetate;19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17?)-;BRD-K96037667-001-01-4;19-Norethindrone acetate, VETRANAL(TM), analytical standard;FEMHRT COMPONENT NORETHINDRONE ACETATE;19-Nor-17alpha-ethynyltestosterone Acetate;CAS-51-98-9;SH-420;NCGC00183366-07;17-alpha-Ethynyl-19-nortestosterone acetate;Orlutate;Norethisterone acetate (Norethindrone acetate);17-alpha-Ethynyl-17-hydroxyestr-4-en-3-one acetate;19-Nor-17alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-, acetate;19-Norethynyltestosterone acetate;C08152;ESTROSTEP FE COMPONENT NORETHINDRONE ACETATE;Norethindrone acetate, United States Pharmacopeia (USP) Reference Standard;17.alpha.-Ethynyl-17.beta.-acetoxy-19-norandrost-4-en-3-one;Gestakadin;AS-13383;NORETHINDRONE ACETATE [MI];T72561;norethindrone-acetate;NSC-22844;Norethindrone acetate [USP];N0450;19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17alpha);BCP11908;CS-7730;17-Hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one acetate;IMONTRJLAWHYGT-ZCPXKWAGSA-N;19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17.alpha.)-;19-Norethisterone acetate;19-nor-17.alpha.-Pregn-4-en-20-yn-3-one, 17-acetoxy-;(1S,11S,15S,2R,10R,14R)-14-ethynyl-15-methyl-5-oxotetracyclo[8.7.0.0<2,7>.0<11 ,15>]heptadec-6-en-14-yl acetate;19-nor-17alpha-Pregn-4-en-20-yn-3-one, 17-acetoxy-;SH 420;17beta-Acetoxy-19-nor-17alpha-pregn-4-en-20-yn-3-one;NSC22844;NORETHINDRONE ACETATE COMPONENT OF TRI-LEGEST FE;Norethisterone acetate;CCRIS 485;17.alpha.-Ethynyl-19-nortestosterone acetate;Miniphase;D0T6RH;Tox21_113371;Norethynyltestosterone acetate;9S44LIC7OJ;HMS3259A16;NORETHINDRONE ACETATE [USP-RS];Progylut;LO LOESTRIN FE COMPONENT NORETHINDRONE ACETATE;17-alpha-Ethynyl-17-beta-acetoxy-19-norandrost-4-en-3-one;NORETHISTERONI ACETAS [WHO-IP LATIN];AKOS016010517;Norethindrone 17-acetate;CPD001906776;DTXCID601071;HY-B1710;NORETHISTERONE ACETATE [JAN];NORETHINDRONE ACETATE COMPONENT OF FEMHRT;UNII-9S44LIC7OJ;Progestin (transdermal patch, female contraception), Watson Pharmaceuticals;17.beta.-Acetoxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one;17alpha-Ethinyl-19-nortestosterone-17beta-acetate;NSC 22844;NORETHISTERONE ACETATE [EP MONOGRAPH];Aygestin;19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-acetoxy-;(17beta)-17-ethynyl-3-oxoestr-4-en-17-yl acetate;17-Hydroxy-19-nor-17.alpha.-pregn-4-en-20-yn-3-one acetate;NC00575;Norethindrone acetate;17-Acetyloxy(17.alpha.)-19-norpregn-4-estren-17.beta.-ol-acetate-3-one;17alpha-Ethynyl...
Cas No.	51-98-9
分子式	C₂₂H₂₈O₃
分子量	340.46
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Norethindrone acetate 是一种雌性激素，可用于子宫内膜异位症研究。

生物活性

Norethindrone acetate is a female hormone used for the research of endometriosis.

性状

Solid

IC50 & Target[1][2]

Progesterone Receptor

体内研究(In Vivo)

Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, b

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7.
[2]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (293.72 mM)H₂O : 0.67 mg/mL (1.97 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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