CREBtide|149155-45-3|-陌孚医药/Medlife

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CREBtide

目录号: PL09865 纯度: ≥98%

CAS No. :149155-45-3

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中文名称	CREBtide
英文名称	CREBtide
英文别名	L-Arginine,L-lysyl-L-arginyl-L-arginyl-L-a-glutamyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-L-arginyl-L-prolyl-L-seryl-L-tyrosyl-;L-Arginine,L-lysyl-L-arginyl-L-arginyl-L-a-glutamyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-L-a...;L-Arginine,L-lysyl-L-arginyl-L-arginyl-L-a-glutamyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-L-arginyl-L-prolyl-L-seryl-L-tyros;Crebtide;Krreilsrrpsyr;CREBtide
Cas No.	149155-45-3
分子式	C₇₃H₁₂₉N₂₉O₁₉
分子量	1716.99
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	CREBtide 是一种合成的含 13 个氨基酸的肽，作为一种 PKA 底物。
生物活性	CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
性状	Solid
IC50 & Target[1][2]	PKA
体外研究(In Vitro)	delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent Km of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (Km=39 μM), the synthetic peptide substrate most often employed for cAK measurement. The Vmax values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent Km of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the Vmax value is 3.2 mumol/(min.mg). Both delta-CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibi
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	KRREILSRRPSYR
Sequence	Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg
参考文献	[1]. Wu J, et al. A microPLC-based approach for determining kinase-substrate specificity. Assay Drug Dev Technol. 2007 Aug;5(4):559-66. [2]. Colbran JL, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1277-82.

溶解度数据	In Vitro: H₂O : 100 mg/mL (58.24 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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