IWP L6|1427782-89-5|(Porcn Inhibitor III)-陌孚医药/Medlife

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IWP L6 (Synonyms: Porcn Inhibitor III)

目录号: PL09923 纯度: ≥99%

CAS No. :1427782-89-5

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中文名称	IWP L6
中文别名	IWP-L6 抑制剂;N-(5-苯基-2-吡啶基)-2-[(3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2-D]嘧啶-2-基)硫基]乙酰胺
英文名称	IWP L6
英文别名	IWP-L6;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)aceta;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide;Iwp l6;Porcn Inhibitor III;C25H20N4O2S2;2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide;AOB2791;QESQGTFWEQMCMH-UHFFFAOYSA-N;HMS3653I10;BCP08956;2487AH;s7301;BDBM50428008;SB19438;BC600422;SW219907-1;N-(5-;IWP L6
Cas No.	1427782-89-5
分子式	C₂₅H₂₀N₄O₂S₂
分子量	472.58
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	IWP L6 (Porcn Inhibitor III) 是高活性 Porcn 抑制剂，EC₅₀ 为 0.5 nM。
生物活性	IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC 50 of 0.5 nM.
性状	Solid
IC50 & Target[1][2]	EC50 Value: 0.5 nM
体外研究(In Vitro)	IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Wang, X., et al., The development of highly potent inhibitors for porcupine. J Med Chem, 2013. 56(6): p. 2700-4.

溶解度数据	In Vitro: DMSO : 1.43 mg/mL (3.03 mM; Need ultrasonic)配制储备液

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