(+)-Cloprostenol|54276-21-0|(D-Cloprostenol)-陌孚医药/Medlife

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(+)-Cloprostenol (Synonyms: D-Cloprostenol)

目录号: PL10114 纯度: ≥98%

CAS No. :54276-21-0

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中文名称	(+)-Cloprostenol
中文别名	( )-氯前列烯醇;(5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-氯苯氧基)-3-羟基-1-丁烯-1-基]-3,5-二羟基环戊基]-5-庚烯酸;(+)-氯前列醇;(+)-氯前列烯醇;氯前列烯醇
英文名称	(+)-Cloprostenol
英文别名	( )-Cloprostenol;(5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid;(+)-Cloprostenol;(+/-)-9-methyl-3,9-diazabicyclo[4.2.1]nonane;(Z)-7-(2-((E)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid;3,9-Diazabicyclo[4.2.1]nonane,9-methyl-;9-methyl-3,9-diazabicyclo-[4.2.1]nonane;9-methyl-3,9-diazabicyclo-[4.2.1]-nonane;9-METHYL-3,9-DIAZABICYCLO[4.2.1]NONANE;ACMC-20m5i7;AGN-PC-00BJCD;Cloprostenol;CTK4;SureCN929913
Cas No.	54276-21-0
分子式	C₂₂H₂₉ClO₆
分子量	424.92
包装储存	Pure form -20°C 3 years；4°C 2 years

产品详情	(+)-Cloprostenol 是前列腺素 F2α 的类似物，为选择性的 prostaglandin receptor 激动剂。
生物活性	(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
性状	Oil
IC50 & Target[1][2]	PGF2α
体外研究(In Vitro)	D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Manca R, et al. Intra-vesicle administration of D-cloprostenol for induction of abortion in mid-gestation bitches. Anim Reprod Sci. 2008 Jun;106(1-2):133-42. Epub 2007 Apr 21. [2]. Re G, et al. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2 alpha receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharmacol Ther. 1994 Dec;17(6):455-8.

溶解度数据	In Vitro: DMSO : 100 mg/mL (235.34 mM; Need ultrasonic)Ethanol : 50 mg/mL (117.67 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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