Bisindolylmaleimide X hydrochloride|145317-11-9|(BIM-X hydrochloride; Ro31-8425 hydrochloride)-陌孚医药/Medlife

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Bisindolylmaleimide X hydrochloride (Synonyms: BIM-X hydrochloride; Ro31-8425 hydrochloride)

目录号: PL09905 纯度: ≥99%

CAS No. :145317-11-9

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中文名称	Bisindolylmaleimide X hydrochloride
英文名称	Bisindolylmaleimide X hydrochloride
英文别名	Bisindolylmaleimide X Hydrochloride;3-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride (1:1);Bisindoylmaleimide X HCl;1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy;1H-Pyrrole-2,5-dione,3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, (Hydrochloride) (1:1);bisindolylmaleimide x;Bisindolylmaleimide X HCl;Bisindolylmaleimide X (hydrochloride);C26H24N4O2.HCl;SYN1021;IMBOYWXMTUUYGZ-UHFFFAOYSA-N;BCP20648;2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl;B;BCP25394;Bisindolylmaleimide X hydrochloride
Cas No.	145317-11-9
分子式	C₂₆H₂₅ClN₄O₂
分子量	460.96
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) 是一种有效的，选择性的蛋白激酶 C (PKC) 抑制剂。Bisindolylmaleimide X hydrochloride 也是一种有效的细胞周期蛋白依赖性激酶 2 (CDK2) 拮抗剂，IC₅₀ 为 200 nM。
生物活性	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC 50 of 200 nM.
性状	Solid
IC50 & Target[1][2]	CDK2 200 nM (IC50) PKC
体外研究(In Vitro)	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Brehmer D, et al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.

溶解度数据	In Vitro: DMSO : 20.83 mg/mL (45.19 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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