A2793 是有效的 TWIK 相关酸敏感 K⁺ 通道 1 (TASK-1)/TRESK 的抑制剂，其对 mTRESK 的 IC₅₀ 值为 6.8 μM。A2764 对 TRESK 选择性更好, 对 TREK-1 和 TALK-1 相对弱一些。

A2793 is an efficient dual TWIK-related acid-sensitive K channel (TASK)-1/TRESK inhibitor, with an IC 50 of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1.

Solid

IC50: 6.8 μM (mTRESK).

A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
A2793 inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influencesTREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；In solvent -80°C 6 months

[1]. Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.

In Vitro: DMSO : 100 mg/mL (376.38 mM; Need ultrasonic)配制储备液