Hexachlorophene (Hexachlorofen) 是一种有效的抗菌 (antibacterial) 剂， 抗真菌 (antifungal) 剂。Hexachlorophene可导致原生质体的裂解和细菌内容物的渗漏。Hexachlorophene 是 SARS-CoV 3CL 蛋白酶抑制剂，其 IC₅₀ 值为 5 μM。Hexachlorophene 也是一种有效的 KCNQ1/KCNE1 钾通道激活剂，其 EC₅₀ 值为 4.61 μM。Hexachlorophene 还可抑制 Wnt/β-catenin 信号通路，可用于心律失常，细菌，癌症等方面的研究。

Hexachlorophene (Hexachlorofen) is an effective anti-bacterial and antifungal agent. Hexachlorophene can cause lysis of protoplasts and leakage of intracellular contents in bacterial. Hexachlorophene is an inhibitor of SARS-CoV 3CL protease with an IC 50 value of 5 μM. Hexachlorophene is also a potent KCNQ1/KCNE1 potassium channel activator with an EC 50 value of 4.61 μM. Hexachlorophene inhibits Wnt/β-catenin signaling as well, and can be used in the research of arrhythmia, bacterial, cancers.

Solid

EC50: 4.61 μM (KCNQ1/KCNE1);
IC50: 5 μM (SARS-CoV)

Hexachlorophene (0.1-10 μM approximately) increases the current amplitude of KCNQ1/KCNE1 with an EC50 value of 4.61 μM, and shortens the action potential.
Hexachlorophene (10 μM) rescues the loss of function of the LQTs mutants caused by either impaired activation gating or PIP2 binding affinity in CHO cells.
Hexachlorophene (0-50 μg/mL approximately, 30 min) has antibacterial activities against micrococcus sp ., staphylococcus , staphylococcus epidermidis and streptococcus with IC50 values of 0.83 μg/mL, 1.5 μg/mL, 1.75 μg/mL, 1.3 μg/mL, respectively.
Hexachlorophene (20 μM, 15 h) inhibits Wnt/β-catenin signaling through the Siah-1-mediated β-catenin degradation in HEK293 and HCT116 cells.
Hexachlorophene (0-10 μM, 48 h) inhibits the growth of HCT116 cells.
Hexachlorophene is a competitive inhibitor of SARS-C

Hexachlorophene (tail immersion for 5 minutes, 1.25% w/v, one day prior to cercarial exposure) has inhibitory activity against Schistosoma mansoni infections in mice (exposed to WRAIR,Puerto Rican strain).
Hexachlorophene has acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Zheng Y, et al. Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. PLoS One. 2012;7(12):e51820.
[2]. Lloyd WJ, et al. Cyclohexane triones, novel membrane-active antibacterial agents. Antimicrob Agents Chemother. 1988 Jun;32(6):814-8.
[3]. Seoyoung Park, et al. Hexach

In Vitro: DMSO : ≥ 100 mg/mL (245.76 mM)H₂O : 0.1 mg/mL (0.25 mM; Need ultrasonic)