Rp-cAMPS sodium salt|142439-94-9|-陌孚医药/Medlife

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Rp-cAMPS sodium salt

目录号: PL09867 纯度: ≥99%

CAS No. :142439-94-9

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中文名称	Rp-cAMPS sodium salt
英文名称	Rp-cAMPS sodium salt
英文别名	SP-CYCLIC 3,5-HYDROGEN PHOSPHOROTHIOATE ADENOSINE SODIUM SALT;RP-CAMPS NA;RP-CAMPS SODIUM SALT;ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT;ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT;CAMPS NA RP-ISOMER;Rp-cAMPS sodium salt
Cas No.	142439-94-9
包装储存	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Rp-cAMPS sodium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (K_i 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。
生物活性	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K i s of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases.
性状	Solid
IC50 & Target[1][2]	Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)
体外研究(In Vitro)	A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60. [2]. Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3,5-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62.

溶解度数据	In Vitro: H₂O : 250 mg/mL (680.74 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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