3-Methyltoxoflavin 是蛋白质二硫键异构酶 (PDI) 的有效抑制剂，其 IC₅₀ 值为 170 nM。

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC 50 of 170 nM.

Solid

IC50: 170 nM (PDI).

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy. Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis. has not independently confirmed the accuracy of these methods. They are for refere

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Kyani A, et al. Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma. ChemMedChem. 2018 Jan 22;13(2):164-177.

In Vitro: DMSO : 50 mg/mL (241.32 mM; ultrasonic and warming and heat to 60°C)配制储备液