Bis(maltolato)oxovanadium(IV)|38213-69-3|(BMOV)-陌孚医药/Medlife

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Bis(maltolato)oxovanadium(IV) (Synonyms: BMOV)

目录号: PL09537 纯度: ≥99.0%

CAS No. :38213-69-3

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中文名称	Bis(maltolato)oxovanadium(IV)
中文别名	双(麦芽醇)氧钒(IV);甲基麦芽酚氧钒
英文名称	Bis(maltolato)oxovanadium(IV)
英文别名	Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-;Bis(maltolato)oxovanadium(IV);2-methyl-4-oxopyran-3-olate,oxovanadium(2+);(SP-5-31)-bis(3-hydroxy-2-methyl-4H-pyran-4-onato-O3,O4)oxo-vanadium
Cas No.	38213-69-3
分子式	₂[C₆H₅O₃-]^.OV+₂
分子量	317.15
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效，可逆，竞争性和具有口服活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。Bis(maltolato)oxovanadium(IV) 抑制 HCPTPA，PTP1B，HPTPβ 和 SHP2 的 IC₅₀ 分别为 126 nM，109 nM，26 nM 和 201 nM。Bis(maltolato)oxovanadium(IV) 是一种有效的胰岛素增敏剂。
生物活性	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC 50 s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer.
性状	Solid
IC50 & Target[1][2]	IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)
体外研究(In Vitro)	Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Janine Krüger, et al. Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice. FEBS Open Bio. 2016 Jan 4;6(3):179-89. [2]. Kevin G Peters, et al. Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component. J Inorg Biochem. 2003 Aug 1;96(2-3):321-30.

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