MAFP|188404-10-6|(Methyl Arachidonyl Fluorophosphonate)-陌孚医药/Medlife

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MAFP (Synonyms: Methyl Arachidonyl Fluorophosphonate)

目录号: PL09491 纯度: ≥98%

CAS No. :188404-10-6

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中文名称	MAFP
中文别名	P-(5Z,8Z,11Z,14Z)-5,8,11,14-二十碳四烯-1-基-氟膦酸甲酯
英文名称	MAFP
英文别名	Phosphonofluoridicacid, P-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-, methyl ester;MAFP;(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester;MAFP,(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-methylesterphosphonofluoridicacid;(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenyl-Methylesterphosphonofluoridicacid;5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID,METHYL ESTER;MAPF;MAPF,Phosphonofluoridic acid,methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester;METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE;METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER;Phosphonofluoridicacid;METHYL ARACHIDONYL FLUOROPHOSPHONATE;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester;Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester;(5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene;5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER
Cas No.	188404-10-6
分子式	C₂₁H₃₆FO₂P
分子量	370.48
包装储存	Pure form -20°C 3 years；In solvent -80°C 6 months

产品详情	MAFP (Methyl Arachidonyl Fluorophosphonate) 是选择性，针对活性位点，不可逆的 cPLA2 和 iPLA2 抑制剂。 MAFP也是一种有效的不可逆的 anandamide amidase 抑制剂。
生物活性	MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
性状	Liquid
IC50 & Target[1][2]	cPLA2, iPLA2, Anandamide amidase
体外研究(In Vitro)	MAFP inhibits iPLA2, in a concentration-dependent manner with an IC50 of 5 μM after a 5 min preincubation at 40°C in P388D1 cells. cPLA, is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile. MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP demonstrates selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. MAFP displaces [H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Lio YC, et al. Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta. 1996 Jul 12;1302(1):55-60. [2]. Deutsch DG, et al. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol. 1997 Feb 7;53(3):255-60.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (269.92 mM)Methyl Acetate : ≥ 10 mg/mL (26.99 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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