Chlorpromazine hydrochloride|69-09-0|(盐酸氯丙嗪)-陌孚医药/Medlife

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Chlorpromazine hydrochloride (Synonyms: 盐酸氯丙嗪)

目录号: PL09488 纯度: ≥99%

CAS No. :69-09-0

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中文名称	Chlorpromazine hydrochloride
中文别名	盐酸氯丙嗪;N,N-二甲基-2-氯-10H-吩噻嗪-10-丙胺盐酸盐;2-氯-10-(3-二甲胺基丙基)吩噻嗪盐酸盐;冬眠灵;可乐静;氯丙嗪;阿米那嗪;氯普马嗪;N,N-二甲基-2-氯-10H-吩噻嗪-10-丙胺;氯丙嗪盐酸盐;Chlorpromazine Hydrochloride 氯丙嗪盐酸盐;WAKO036-19611盐酸氯丙嗪标准品;大量***丙嗪;盐酸氯丙嗪 EP标准品;盐酸氯丙嗪 USP标准品;盐酸氯丙嗪标准品;盐酸氯丙嗪冬眠灵;盐酸氯丙嗪治疗精神病;2-氯-10-(3-二甲氨基丙基)吩噻嗪盐酸盐;氯丙嗪盐酸盐
英文名称	Chlorpromazine hydrochloride
英文别名	chloropromazine hydrochloride;Chlorpromazine hydrochloride;Chlorpromazine HCL;Chlorpromazine;2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HCL;2-CHLORO-10-[3'-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE, HCL;2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HYDROCHLORIDE;2-CHLORO-N,N-DIMETHYL-10H-PHENOTHIAZINE-10-PROPANAMINE, HCL;HEBANIL;LARGACTIL;KLORPROMEX;3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine;[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-dimethylamine hydrochloride;Chlorpromazine (hydrochloride);Chlorpromazine hydrochloride (CPZ, Largactil®, Thorazine®, Megaphen®);Chlorpromazine hydrochloride solution;CHLORPROMAZINE HYDROCHLORIDE, USP GRADE;2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride;CPZ;Thorazine;Contomin;Chloropromazine;Chlorderazin;Aminazine;Chlorpromados;Megaphen;Fenactil;Propaphenin;Clorpromazina;Sanopron;Psychozine;Ampliactil;Torazina;Largactyl;Aminazin;2-Chloropromazine;Wintermin;Fenaktyl;Promazil;Promactil;Phenactyl;Prozil;Esmind;Elmarin;Proma;Chlor-Promanyl;Largactilothiazine;Chlorpromazinum;Chlorpromazin;Novomazina;Fraction AB;Amplictil;SKF 2601-A;Plegomasine;Cromedazine;Ami;3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride.;Hibanil;NSC-17479;MLS002222157;[3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride;Neurazine;Chlorpromazine Hcl Intensol;2-chloro-10-(3-dimethylaminopropyl) phenothiazine hydrochloride;Chlorpromazinium chloride;Aminazinum (for the hydrochloride);Promacid;Hybernal;Largaktyl;chlorpromazinhydrochlorid-;CHLORPROMAZINE HYDROCHLORIDE [EP IMPURITY];FBSMERQALIEGJT-UHFFFAOYSA-N;CAS-69-09-0;Tox21_300517;Unitensen;Chlorpromazine Hcl;Chlorpromazine.HCl;3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine hydrochloride;CHEBI:3649;Megaphen hydrochloride;AC1LCWF1;SR-01000000012;Chlorpromazine hydrochloride, United States Pharmacopeia (USP) Reference Standard;MLS000069401;1329612-87-4;WLN: T C666 BN ISJ B3N1&1 EG &GH;CHLORPROMAZINE HYDROCHLORIDE [EP MONOGRAPH];CHLOROPROMAZINE HYDROCHLORIDE;Chlorpromazine Hydrochloride Intensol;CPZ (VAN);AI3-28023;LP00249;Hibernal;C17H19ClN2S.ClH;Promapar;Z104477466;MFCD00012654;Sonazine;10-(3-Dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride;10H-phenothiazine-10-propanamine hydrochloride, 2-chloro-N,N-dimethyl-;SMR000058254;MLS001148603;Tox21_500249;Chloractil;SR-01000000012-2;4560 Rp hydrochloride;SCHEMBL41771;CHLORPROMAZINE HYDROCHLORIDE [VANDF];Aminazinum;NSC17479;EINECS 200-701-3;3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride;9WP59609J6;Chlorpromazine, Hydrochloride;Fenactil monohydrochloride;Chloropromazin hydrochloride;Chlorpromazin-d6 hydrochloride;CHLORPROMAZINE HYDROCHLORIDE [USP MONOGRAPH];2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine monohydrochloride;NSC226514;Klorpromex;69-09-0 (HCl);Chlorpromazine hydrochloride, 98%;Promexin;Phenothi...
Cas No.	69-09-0
分子式	C₁₇H₁₉ClN₂S
分子量	318.86
包装储存	4°C, sealed storage, away from moisture and light 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

产品详情	Chlorpromazine hydrochloride 是一种口服有效的、可透过血脑屏障的抗精神病剂，能有效拮抗 D2 多巴胺受体和 5-HT_2A，已广泛用于精神分裂症和其他精神疾病。Chlorpromazine hydrochloride 可通过多种途径发挥抗癌活性，包括抗增殖、诱导自噬和周期停滞 (G2-M 期)、抑制细胞色素 c 氧化酶 (CcO)、抑制肿瘤生长和转移以及抑制肿瘤免疫逃逸等。Chlorpromazine hydrochloride 还能阻断 hNa_v1.7 通道 (IC₅₀=25.9 μM; 浓度依赖的方式) 和 HERG 钾通道 (IC₅₀=21.6 μM) ，其在止痛以及心律失常方面也具有较好的研究潜力。Chlorpromazine hydrochloride 也能抑制网格蛋白介导的内吞作用。
生物活性	Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT 2A , which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa v 1.7 channels (IC 50 =25.9 μM; concentration-dependent) and HERG potassium channels (IC 50 =21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
性状	Solid
IC50 & Target[1][2]	D2 dopamine receptors; 5-HT2A.
体外研究(In Vitro)	Chlorpromazine hydrochloride (0, 10, 20, 40 μM; 0, 24, 48 h) inhibits growth of U-87MG glioma cells in a dose- and time- dependent manner. Chlorpromazine hydrochloride (20 μM; 0, 12, 24, 48 h) decreases the levels of cyclin A and cyclin B1 in U-87MG glioma cells, 12 h later. Chlorpromazine hydrochloride (20 μM) causes inhibition of cell cycle progression. Chlorpromazine hydrochloride (10 μM; 1 h) significantly suppresses the sEV internalization and dramatically reduces MDSCs in sEV-treated bone marrow cells (MDSCs can significantly suppress the immune cell response, causing immunosuppression in cancer cells). Chlorpromazine hydrochloride (3, 10, 20, 40, 60 μM) blocks the hNav1.7 current in a concentration-dependent manner. Chlorpromazine hydrochloride blocks HERG potassium channels with an IC50 value of 21.6 μM and a Hill coefficient
体内研究(In Vivo)	Chlorpromazine hydrochloride (20 mg/kg; i.p.; single daily for 7 days) inhibits xenograft tumor growth in nude mouse. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 5- to 6-week-old
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light 该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献	[1]. Kamgar-Dayhoff P, et al. Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment. Oncotarget. 2021 Jul 6;12(14):1406-1426. [2]. Shin SY, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9.

溶解度数据	In Vitro: H₂O : 100 mg/mL (281.43 mM; Need ultrasonic)DMSO : ≥ 60 mg/mL (168.86 mM)

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