SRI-011381 hydrochloride|2070014-88-7|-陌孚医药/Medlife

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SRI-011381 hydrochloride

目录号: PL09452 纯度: ≥99%

CAS No. :2070014-88-7

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PL09452-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1007.64	请登录

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中文名称	SRI-011381 hydrochloride
英文名称	SRI-011381 hydrochloride
英文别名	SRI-011381 hydrochloride;1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea;hydrochloride;SRI011381HCl;SRI011381 HCl;BCP30374;SRI011381 hydrochloride;SRI011381 HCl;1-Benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea hydrochloride
Cas No.	2070014-88-7
分子式	C₂₀H₃₂ClN₃O
分子量	365.94
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	SRI-011381 hydrochloride 是一种有具有口服生物活性的 TGF-β 信号通路的激活剂，具有神经保护作用。
生物活性	SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
性状	Solid
IC50 & Target[1][2]	TGF-beta
体外研究(In Vitro)	SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med [2]. Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (91.08 mM; Need ultrasonic)H₂O : 25 mg/mL (68.32 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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