Imipramine hydrochloride|113-52-0|(盐酸丙咪嗪)-陌孚医药/Medlife

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Imipramine hydrochloride (Synonyms: 盐酸丙咪嗪)

目录号: PL09450 纯度: ≥99%

CAS No. :113-52-0

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中文名称	Imipramine hydrochloride
中文别名	丙咪嗪;盐酸丙咪嗪;咪帕明;N,N-二甲基-10,11-二氢-5H-二苯并[b,f]氮杂卓-5-丙胺盐酸盐;托弗尼尔;丙咪嗪盐酸;丙咪嗪盐酸盐;4-羟基-3-甲氧苯丙酮酸;Imipramine Hydrochloride 丙咪嗪盐酸盐;丙咪嗪标准品(JP);盐酸丙咪嗪 EP标准品;盐酸丙咪嗪 USP标准品;盐酸盐丙咪嗪标准品;马来酸三甲丙咪嗪杂质D(EP) 标准品;盐酸氯米帕明杂质B(EP);10,11-二氢-N,N-二甲基-5H-二苯并[b,f]吖庚因-5-丙胺盐酸盐;5-[3-(二甲氨基)丙基]-10,11-二氢-5H-二苯并[b,f]吖庚因盐酸盐;丙咪嗪盐酸盐标准品;盐酸丙咪嗪溶液, 100PPM
英文名称	Imipramine hydrochloride
英文别名	Imipramine hydrochloride;10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine;5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride;5H-dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-,monohydrochloride;antideprinhydrochloride;chimoreptin;chrytemin;cocapimipramine25;deprinol;Imipramine (hydrochloride);Imipramine hydrochloride solution;10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride;5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride;10,11-Dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-5-propanamine Hydrochloride;5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine Hydrochloride;10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine hydrochloride;g22355;imidol;ia-pram;imavate;iprogen;dynazina;efuranol;fujisawa;janimine;imipramine;Melipramine;Imidobenzyle;Antideprin;Melipramin;Berkomine;Dimipressin;Tofranil;Nelipramin;Prazepine;Intalpram;Dynaprin;Timolet;Irmin;Dpid;Dyna-zina;Impramine;Promiben;Iramil;Imiprin;Censtin;Censtim;Imipramina;Declomipramine;Psychoforin;Imipraminum;Imipramin;Eupramin;Imizine;Surplix;Imizin;Tofranil, base;Imipramina [Italian];Tofranil-PM;SK-Pramine;Imipramine [INN:BAN];Imipraminum [INN-Latin]
Cas No.	113-52-0
分子式	C₁₉H₂₄N₂
分子量	280.41
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Imipramine hydrochloride 是一种具有口服活性的叔胺类三环抗抑郁药。Imipramine hydrochloride 是一种具有抗肿瘤活性的 Fascin1 抑制剂。Imipramine hydrochloride 也抑制 5-羟色胺转运体 (serotonin transporter)，其 IC₅₀ 值为 32 nM。Imipramine hydrochloride 刺激 U-87MG 胶质瘤细胞自噬（autophagy），诱导 HL-60 细胞凋亡（apoptosis）。Imipramine hydrochloride 具有神经保护和免疫调节作用。

生物活性

Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC 50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects.

性状

Solid

IC50 & Target[1][2]

Fascin1, Serotonin Autophagy, Apoptosis
IC50: 32 nM (human placental serotonin transporter)

体外研究(In Vitro)

Imipramine (0.5-300 μM, 3 days) inhibits HCT-116 cell viability.
Imipramine (20 μM) inhibits cell migration (7 h) and invasion (48 h).
Imipramine (50 μM, 0-240 min) inhibites the PI3K/Akt/mTOR signaling pathway in U-87MG glioma cells.
Imipramine (60 μM, 24 h) stimulates U-87MG glioma cells autophagy.
Imipramine (80 μM, 24 h) induces HL-60 cell apoptosis. has not independently confirmed the accuracy of these methods. They are for reference only.-

体内研究(In Vivo)

Imipramine (20 mg/kg, i.p. or 15 mg/kg, p.o.; daily for 24 days) attenuates neuroinflammatory signaling and reverses stress-induced social avoidance in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292.
[2]. Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (315.59 mM)H₂O : 62.5 mg/mL (197.24 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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