(+)-PD 128907 hydrochloride|300576-59-4|-陌孚医药/Medlife

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(+)-PD 128907 hydrochloride

目录号: PL09202 纯度: ≥99%

CAS No. :300576-59-4

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中文名称	(+)-PD 128907 hydrochloride
中文别名	(+)-PD 128907, 盐酸盐;PD 128907盐酸盐;(4AR,10AR)-1-丙基-2,3,10,10A-四氢-1H,4AH-4,9-二氧杂-1-氮杂菲-6-醇盐酸盐;(+)-PD 128907 盐酸盐;(4aR,10aR)-1-丙基-2,3,10,10a-四氢-1H,4aH-4,9-二氧杂-1-氮杂菲-6-醇盐酸盐
英文名称	(+)-PD 128907 hydrochloride
英文别名	(4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol;(+)-PD 128907 HYDROCHLORIDE;(4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, hydrochloride;2H,5H-[1]Benzopyrano[4,3-b]-1,4-oxazin-9-ol,3,4,4a,10b-tetrahydro-4-propyl-, hydrochloride (1:1), (4aR,10bR)-;PD 128907 hydrochloride;(+)-PD128907;(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride;(4aR,10aR)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-azaphenanthren-6-ol hydrochloride;(+)-PD 128907 hydrochloride
Cas No.	300576-59-4
分子式	C₁₄H₁₉NO₃
分子量	249.31
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	(+)-PD 128907 hydrochloride 是多巴胺D₂/D₃ 受体的选择性激动剂，其在人类和大鼠中对D₃ 的 K_i 值分别为0.7，0.84 nM，对D₂ 的K_i 值分别为179，770 nM。
生物活性	(+)-PD 128907 hydrochloride is a selective dopamine D 2 /D 3 receptor agonist, with K i s of 1.7, 0.84 nM for human and rat D 3 receptors, 179, 770 n M for human and rat D 3 receptors, respectively.
性状	Solid
IC50 & Target[1][2]	Ki: 1.7 nM (human D3 receptor), 0.84 nM (rat D3 receptor), 179 nM (human D2 receptor), 770 nM (rat D2 receptor).
体外研究(In Vitro)	(+)-PD 128907 displaced [H]spiperone binding from dopamine D3 receptors (Ki human=1.7 nM and rat=0.84 nM) with >100-fold and 900-fold selectivity over the human (Ki=179 nM) and rat (Ki=770 nM) dopamine D2 receptor. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	(+)-PD 128907 significantly decreases dialysate DA levels in D 3 knock out mice. The IC 25 values are 61 nM and 1327 nM, respectively, for wild type and D 3 knock out mice. The ratio of the IC 25 values shows that (+)-PD 128907 is 22 times more potent in decreasing dialysate DA levels in wild type as compared to mice lacking the D 3 receptor. The D3 agonist evokes a dose related decrease in dialysate DA in wild type mice. Post-hoc analysis shows that all doses tested (0.03, 0.1 and 0.3 mg/kg) significantly inhibit dialysate DA. The IC 25 values are 0.05 and 0.44 mg/kg for wild type and knock out mice, respectively, indicating that systemically administered (+)-PD 128907 is 9 times more potent in decreasing dialysate DA in the ventral striatum of wild type as compared to D 3 knock out mice. Doses of 1 mg/kg or
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Collins GT, et al. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior. J Pharmacol Exp Ther. 2005 Jul;314(1):310-9. [2]. Bristow LJ, et al. The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology. 1996 Mar;35(3):285-94.

溶解度数据	In Vitro: DMSO : 20.83 mg/mL (72.89 mM; Need ultrasonic)H₂O : 16.67 mg/mL (58.33 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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