(Arg)9 acetate||-陌孚医药/Medlife

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(Arg)9 acetate

目录号: PL09371 纯度: ≥99%

商品编号	规格	价格	会员价
PL09371-1mg	1mg	¥1483.64	请登录
PL09371-5mg	5mg	¥4760.00	请登录
PL09371-10mg	10mg	¥7418.18	请登录
PL09371-50mg	50mg	询价	询价
PL09371-100mg	100mg	询价	询价

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中文名称	(Arg)9 acetate
英文名称	(Arg)9 acetate
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情

(Arg)9 (Nona-L-arginine) acetate 是一种由 9 个精氨酸残基组成的细胞穿透肽 (CPP)。(Arg)9 acetate 具有神经保护功能，在谷氨酸模型中 IC₅₀ 值为 0.78 μM。

生物活性

(Arg)9 (Nona-L-arginine) acetate is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 acetate has neuroprotective property, exhibits neuroprotective activity with an IC 50 of 0.78 μM in the glutamic acid model.

性状

Solid

IC50 & Target[1][2]

IC50: 0.78 μM (neuroprotection)

体外研究(In Vitro)

(Arg)9 (Nona-L-arginine; 5-10 μM) acetate provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 acetate is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 acetate also shows neuroprotection following in vitro ischemia (IC50=6 μM). has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

(Arg)9 (Nona-L-arginine; 1?μM/kg (600? μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) acetate shows neuroprotective effects and reduces infarct volume. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

ClinicalTrial

SequenceShortening

RRRRRRRRR

参考文献

[1]. Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81.
[2]. Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004.

溶解度数据	In Vitro: H₂O : 100 mg/mL (67.40 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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