PCPA methyl ester hydrochloride|14173-40-1|(4-Chloro-DL-phenylalanine methyl ester hydrochloride)-陌孚医药/Medlife

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PCPA methyl ester hydrochloride (Synonyms: 4-Chloro-DL-phenylalanine methyl ester hydrochloride)

目录号: PL09228 纯度: ≥99%

CAS No. :14173-40-1

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PL09228-5g	5g	询价	询价
PL09228-10g	10g	询价	询价

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中文名称	PCPA methyl ester hydrochloride
中文别名	4-氯-DL-苯丙氨酸甲酯盐酸盐;4-氯-DL-苯基丙氨酸甲酯盐酸盐;对-氯-dl-苯基丙氨酸甲基酯盐酸;扎那米韦;4-氯-DL-苯基丙氨酸甲酯;盐酸-DL-4-氯苯丙氨酸甲酯;DL-4-氯苯丙氨酸甲酯盐酸盐;对-氯-DL-苯基丙氨酸甲基酯盐酸盐;4-氯-DL-苯基丙氨酸甲酯盐酸盐
英文名称	PCPA methyl ester hydrochloride
英文别名	4-Chloro-DL-phenylalanine methyl ester hydrochloride;Methyl 4-chloro-3-phenyl-DL-alaninate hydrochloride;DL-4-Chlorophenylalanine Methyl Ester Hydrochloride;4-Chloro-dl-phenylalanine methyl ester, HCl;4-Chloro-DL-Phe-OMe·HCl;H-DL-PHE(4-CL)-OME HCL;H-DL-Phe(4-Cl)-OMe.HCl;H-p-Chloro-DL-Phe-OMe · HCl;Methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride;4-Chloro-DL-Phe-OMe HCl;4-Chloro-DL-Phe-OMe.HCl;TIMTEC-BB SBB003149;H-p-Chloro-DL-Phe-OMe;p-Chloro-DL-Phe-OMe·HCl;H-P-CHLORO-DL-PHE-OME HCL;4-Chloro-DL-Phe-OMe•p-Chlorophenylalanine methyl;P-CHLORO-DL-PHENYLALANINE HCL;dl-pcpamethylesterhydrochloride;DL-p-Chlorophenylalanine methyl ester hydrochloride;4-Chloro-L-phenylalanine methyl ester hydrochloride;(RS)-2-Amino-3-(4-chloro-phenyl)-propionic acid methyl ester HCl;H-4-Chloro-DL-Phe-OMe HCl;(R)-Methyl 2-amino-3-(4-chlorophen;PCPA methyl ester hydrochloride
Cas No.	14173-40-1
分子式	C₁₀H₁₃Cl₂NO₂
分子量	250.12
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是一种可逆的色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂，是 5-羟色胺 (5-HT) 合成抑制剂。PCPA methyl ester hydrochloride 可穿过血脑屏障，并降低 5-HT 的中枢利用率。
生物活性	PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability.
性状	Solid
IC50 & Target[1][2]	serotonin Tryptophan Hydroxylase
体内研究(In Vivo)	PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex. In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Dool-Ri Oh, et al. Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABA A-ergic systems: Involvement of 5-HT 1A receptor agonistic activity. Biomed Pharmacother. 2019 Jan;109:2218-2227. [2]. Fabio Bellia, et al. Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice. Psychopharmacology (Berl). 2021 Jan;238(1):215-225.

溶解度数据	In Vitro: H₂O : 50 mg/mL (199.90 mM; ultrasonic and warming and heat to 60°C)DMSO : 50 mg/mL (199.90 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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