(Arg)9 TFA|2283335-13-5|-陌孚医药/Medlife

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(Arg)9 TFA

目录号: PL09373

CAS No. :2283335-13-5

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中文名称	(Arg)9 TFA
英文名称	(Arg)9 TFA
英文别名	(Arg)9 TFA salt;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethy;(Arg)9 TFA;Peptide R9 (TFA);Nona-L-arginine (TFA);Peptide R9 (TFA)Nona-L-arginine (TFA);Nonaarginine, H(-Arg)9-OH, (Arg)9 Trifluoroacetate;Nona-L-arginine TFA;Peptide R9 TFA
Cas No.	2283335-13-5
分子式	C₅₆H₁₁₁F₃N₃₆O₁₂
分子量	1537.71
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情

(Arg)9 (Nona-L-arginine) TFA 是一种由 9 个精氨酸残基组成的细胞穿透肽 (CPP)。(Arg)9 TFA 具有神经保护功能，在谷氨酸模型中 IC₅₀ 值为 0.78 μM。

生物活性

(Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC 50 of 0.78 μM in the glutamic acid model.

性状

Solid

IC50 & Target[1][2]

IC50: 0.78 μM (neuroprotection).

体外研究(In Vitro)

(Arg)9 (Nona-L-arginine; 5-10 μM) TFA provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 TFA is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 TFA also shows neuroprotection following in vitro ischemia (IC50=6 μM). has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

(Arg)9 (Nona-L-arginine; 1?μM/kg (600? μL); i.v.; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) TFA shows neuroprotective effects and reduces infarct volume. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

ClinicalTrial

SequenceShortening

RRRRRRRRR

Sequence

Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Solvent&Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:1. Calculate the length of the peptide.2. Calculate the overall charge of the entire peptide according to the following table:

参考文献

[1]. Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81.
[2]. Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004.

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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