Compound 48/80 trihydrochloride|848035-21-2|(C48/80 trihydrochloride)-陌孚医药/Medlife

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Compound 48/80 trihydrochloride (Synonyms: C48/80 trihydrochloride)

目录号: PL09423 纯度: ≥99%

CAS No. :848035-21-2

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中文名称	Compound 48/80 trihydrochloride
中文别名	化合物 T13623
英文名称	Compound 48/80 trihydrochloride
英文别名	Compound 48/80 (hydrochloride);Compound 48/80 (trihydrochloride);2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride;4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine,trihydrochloride;Compound 48/80 hydrochloride;C48/80 trihydrochloride;Compound 48/80 trihydrochloride
Cas No.	848035-21-2
分子式	C₃₂H₄₈Cl₃N₃O₃
分子量	629.10
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
生物活性	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
性状	Solid
体外研究(In Vitro)	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. [2]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104.

溶解度数据	In Vitro: H₂O : 25 mg/mL (39.74 mM; Need ultrasonic)DMSO : 10 mg/mL (15.90 mM; ultrasonic and warming and heat to 60°C)配制储备液

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