Bupropion-d9 (hydrochloride)|1189725-26-5|(Amfebutamone-d-陌孚医药/Medlife

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Bupropion-d9 (hydrochloride) (Synonyms: Amfebutamone-d

目录号: PL09119 纯度: ≥99%

CAS No. :1189725-26-5

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中文名称	Bupropion-d9 (hydrochloride)
中文别名	安非他酮盐酸D9;盐酸安非他酮-D9氘代;盐酸安非他酮 d9 (盐酸盐)
英文名称	Bupropion-d9 (hydrochloride)
英文别名	Bupropion-d9 Hydrochloride;(±)-Bupropion-D9 hydrochloride solution;Bupropion-d9 (hydrochloride);Amfebutamon-d9 Hydrochloride;Amfebutamone-d9 Hydrochloride;Aplenzin-d9 Hydrochloride;Bupropion-d9 SR Hydrochloride;Elontril-d9 Hydrochloride
Cas No.	1189725-26-5
分子式	C₁₃H₉D₉NOCl^.HCl
分子量	285.26
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Bupropion-d₉ (hydrochloride) 是 Bupropion hydrochloride 的氘代物。Bupropion (Amfebutamone) hydrochloride 是一种口服有效，选择性的 5-羟色胺再摄取抑制剂 (SSRI)。Bupropion hydrochloride 阻断多巴胺 (DA) 摄取或 Methamphetamine 诱导的 DA 释放，IC₅₀ 分别为 1.76 μM 和 14.2 μM。Bupro
生物活性	Bupropion-d 9 (hydrochloride) is the deuterium labeled Bupropion hydrochloride. Bupropion (Amfebutamone) hydrochloride is an orally active, selective serotonin reuptake inhibitor (SSRI).Bupropion block dopamine (DA) uptake or Methamphetamine-induced DA release with IC50s of 1.76 μM and 14.2 μM, respectively. Bupropion hydrochloride is an atypical antidepressant of the aminoketone group. Bupropion hydrochloride can be used for the research of smoking cessation aid[1][2][3].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. C Lindsay DeVane. Antidepressant-drug interactions are potentially but rarely clinically significant. Neuropsychopharmacology. 2006 Aug;31(8):1594-604; discussion 1614-5.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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