ABMA 是一种细胞内毒素和病原体的广谱抑制剂。ABMA 有效地保护细胞免受各种毒素和病原体的侵害，包括病毒，细胞内细菌和寄生虫。ABMA 选择性作用于宿主细胞晚期内体，而不是针对毒素或病原体本身，具有广谱抗感染活性。

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity.

Solid

Intracellular bacteria
Viruses
Parasite

ABMA protects cells against four bacterial toxins ( Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3?μM), Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3?μM), rabies (EC50 of 19.4?μM), dengue-4 virus ( EC50 of 8.2?μM)), two species of Chlamydiales intracellular bacteria ( Simkania negevensis and Chlamydia trachomatis ), and the parasite Leishmania infantum (EC50 of 7.1?μM) at micromolar level.
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD 90 of ricin. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Wu Y, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.
[2]. Wu Y, et al. DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS Med Chem Lett. 2019 Jul 2;10(8):1140-1147.

In Vitro: DMSO : 125 mg/mL (356.85 mM; Need ultrasonic)配制储备液