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Chloroquine (Synonyms: 氯喹)

目录号: PL08877 纯度: ≥99%

Chloroquine 是一种广泛用于疟疾和类风湿性关节炎的抗炎试剂。Chloroquine 是自噬 (autophagy) 和 Toll 样受体 (TLRs) 的抑制剂。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。

CAS No. :54-05-7

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中文名称	Chloroquine
中文别名	氯喹盐基;4-(4-二乙氨基-1-甲基丁氨基)-7-氯喹啉;氯喹
英文名称	Chloroquine
英文别名	Chloroquine;4-(4-Diethylamino-1-methylbutylamino)-7-chloroquinoline;CHLORO QUINE PHOSPHATE;N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine;[3H]-Chloroquine;3377 RP;Amokin;Aralen;Bemaco;Imagon;N4-(7-chloroquinoline-4-yl)-N1,N1-diethyl-pentane-1,4-diamine;rp3377;sn7618;w7618;win244;(7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline;n(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-4-pentanediamine;Chlorochin;Chloraquine;Artrichin;Chloroquinium;Reumachlor;Chloroquina;Capquin;Clorochina;Chlorquin;Chemochin;Malaquin;Sanoquin;Cidanchin;Benaquin;Arthrochin;Silbesan;Quinilon;Quinachlor;Klorokin;Heliopar;Gontochin;Chingamin;Sopaquin;Quinoscan;Pfizerquine;Bipiquin;Bemasulph;Tresochin;Solprina;Quinercyl;Mesylith;Lapaquin;Iroquine;Dichinalex;Cocartrit;Roquine;Elestol;Trochin;Neochin;Malarex;Malaren;Siragan;Nivaquine B;Resoquine;Cloroquina;Chloroquinum;CCRIS 3439;Chloroquine, 17;Prestwick3_000548;Resochin (TN);Arechin (Salt/Mix);Prestwick2_000548;SCHEMBL8933;BDBM22985;HMS2090O03;NCGC00162120-01;BRD-A91699651-316-06-7;Chlorochinum;(+-)-N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine;CHLOROQUINE [USP IMPURITY];Tanakene;SPBio_000174;CHLOROQUINE [WHO-DD];n(sup4)-(7-chloro-4-quinolinyl)-n(sup1),4-pentanediamine;EN300-120683;Chlorochine;Chloroquine [USP:INN:BAN];KBio3_001221;NCGC00015256-03;Cloroquina [INN-Spanish];W 7618;1,4-Pentanediamine, N(4)-(7-chloro-4-quinolinyl)-N(1)-,N(1)-diethyl-;CHLOROQUINE [USP MONOGRAPH];NCGC00015256-02;DivK1c_000404;Rivoquine;NCI60_000894;Malaquin (Diphosphate);Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-;CHLOROQUINE [MART.];ST 21 (pharmaceutical);Resoquine (Salt/Mix);Tanakan (Salt/Mix);BPBio1_000655;Chloroquine (USP/INN);C07625;7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline;1,4-Pentanediamine, N(sup 4)-(7-chloro-4-quinolinyl)-N(sup 1),N(sup 1)-diethyl-;MFCD00024009;KBio2_003160;N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine;FT-0623612;NCGC00015256-07;Chloroquine Bis-Phosphoric Acid;N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine;Q422438;Clorochina [DCIT];1,4-Pentanediamine, N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-;UNII-886U3H6UFF;N4-(7-chloro-4-quinolyl)-N1,N1-diethyl-pentane-1,4-diamine;SN 6718;1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-;NINDS_000404;BSPBio_000595;CQ;Prestwick1_000548;WIN 244;N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine;Bemaphate;Spectrum3_000341;Epitope ID:131785;NCGC00015256-06;117399-83-4;HY-17589A;chloroquine;D09EGZ;Spectrum2_000127;NCGC00015256-08;Spectrum_000132;WLN: T66 BNJ EMY1&3N2&2 IG;P01BA01;(+)-N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine;C18H26ClN3;N(C(C)CCCN(CC)CC)c1ccnc2cc(Cl)ccc12;CHLOROQUINE (USP MONOGRAPH);( )-Chloroquine;Chloroquine FNA (TN);Chloroquine (VAN);EINECS 200-191-2;Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)ami...
Cas No.	54-05-7
分子式	C₁₈H₂₆ClN₃
分子量	319.87
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情

Chloroquine 是一种广泛用于疟疾和类风湿性关节炎的抗炎试剂。Chloroquine 是自噬 (autophagy) 和 Toll 样受体 (TLRs) 的抑制剂。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC₅₀=1.13 μM)。

生物活性

Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC 50 =1.13 μM).

性状

Solid

IC50 & Target[1][2]

Plasmodium Malaria

体外研究(In Vitro)

Chloroquine (CHQ, 20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4 T cells. Chloroquine (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduces HuH7 cell proliferation in vitro.
Chloroquine (0.01-100 μM; 48?hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC50=1.13?μM). Chloroquine blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interferin

体内研究(In Vivo)

Chloroquine (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model.
TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

ClinicalTrial

参考文献

[1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
[2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.

溶解度数据	In Vitro: Ethanol : 100 mg/mL (312.63 mM; Need ultrasonic)DMSO : 50 mg/mL (156.31 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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