Bithionol (sulfoxide)|844-26-8|-陌孚医药/Medlife

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Bithionol (sulfoxide)

目录号: PL08851 纯度: ≥98%

CAS No. :844-26-8

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中文名称	Bithionol (sulfoxide)
中文别名	氧硫氯酚
英文名称	Bithionol (sulfoxide)
英文别名	2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol;Bithionol (sulfoxide);BITHIONOL SULFOXIDE;2,2'-sulfinyl-bis(4,6-dichlorophenol);4,6,4',6'-Tetrachlor-2,2'-sulfinyl-di-phenol;4,6,4',6'-tetrachloro-2,2'-sulfinyl-di-phenol;Bis-(3,5-dichlor-2-hydroxyphenyl)sulfoxid;Bis-(3.5-dichlor-2-hydroxy-phenyl)-sulfoxyd;Bithionoloxide;Bithionoloxide [INN];Bithionoloxidum [Latin];Bitin S;Bitionoloxido [Spanish];Disto-5-cogla;Distobitin;Sulphene;Bithionol sulfoxide
Cas No.	844-26-8
分子式	C₁₂H₆O₃Scl₄
分子量	372.05
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Bithionol sulfoxide 是一种针对寄生虫 (parasites) 的抗感染剂 Bithionol sulfoxide 具有诱变活性。Bithionol sulfoxide 可用于寄生虫感染研究，如肺吸虫病、吸虫和绦虫感染。
生物活性	Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection.
性状	Solid
体外研究(In Vitro)	Bithionol sulfoxide (0.1-10 mg/mL, 72 h) shows toxicity to Neoparamoeba spp parasites in sea water. Bithionol sulfoxide (1-1000 μg/plate) exhibits mutagenic activity, in the absence of metabolic activation, in strains TA98 and TA100 (in Salmonella/mammalian microsome test). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Bithionol sulfoxide (oral administration) shows LD 50 values of 1000-5000 mg/kg (mice) and about 5000 mg/kg (rats), and increased serum AST at high doses (5000-100 mg/kg). Bithionol sulfoxide (80 and 90 mg/kg, oral administration) is effective against natural rumen fluke infections in dairy cattle. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. [2]. S P Yang, et al. Treatment of paragonimiasis with bithionol and bithionol sulfoxide. Dis Chest. 1967 Aug;52(2):220-32. [3].

溶解度数据	In Vitro: DMSO : ≥ 250 mg/mL (671.95 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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