(Thr4,Gly7)-Oxytocin|60786-59-6|-陌孚医药/Medlife

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(Thr4,Gly7)-Oxytocin

目录号: PL08660 纯度: ≥99%

CAS No. :60786-59-6

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中文名称	(Thr4,Gly7)-Oxytocin
英文名称	(Thr4,Gly7)-Oxytocin
英文别名	(Thr4,Gly7)-Oxytocin;[THR4,GLY7]-OXYTOCIN;G Oxytocin;[THR4,GLY7] OT;3,3-DiallylthiacarbocyanineBromide;CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2;Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6);H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2;H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2,(DISULFIDE BOND);TGOT;thr(4)-gly(7)-oxytoci;(Thr4,Gly7)-Oxytocin H-Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bond)
Cas No.	60786-59-6
分子式	C₃₉H₆₁N₁₁O₁₂S₂
分子量	940.10
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	(Thr4,Gly7)-Oxytocin, 一种催产素 (Oxytocin) 类似物，是一种特异性 OT 受体激动剂。(Thr4,Gly7)-Oxytocin 还可通过激活 TRPV1 通道和抑制 K⁺ 通道来诱导眼下神经元兴奋。
生物活性	(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K channels. .
性状	Solid
IC50 & Target[1][2]	OT receptors, K channels.
体外研究(In Vitro)	(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons. (Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice. (Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
参考文献	[1]. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. [2]. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415.

溶解度数据	In Vitro: H₂O : 100 mg/mL (106.37 mM; Need ultrasonic)配制储备液

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