Angstrom6|220334-14-5|(A6 Peptide)-陌孚医药/Medlife

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Angstrom6 (Synonyms: A6 Peptide)

目录号: PL08760 纯度: ≥98%

CAS No. :220334-14-5

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中文名称	Angstrom6
英文名称	Angstrom6
英文别名	ANGSTROM6;(S)-4-((S)-1-(acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl)pyrrolidine-2-carboxamido)-5-(((S)-4-amino-1-carboxy-4-oxobutyl)amino)-5-oxopentanoic acid
Cas No.	220334-14-5
分子式	C₃₉H₆₂N₁₀O₁₅
分子量	910.97
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Angstrom6 (A6 Peptide) 是一种来源于单链尿激酶纤溶酶原激活剂 (scuPA) 的8个氨基酸的肽，可干扰 uPA/uPAR 级联反应并消除下游效应。Angstrom6 与 CD44 结合，抑制肿瘤细胞的迁移、侵袭和转移，调节 CD44 介导的细胞信号。
生物活性	Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.
性状	Solid
体外研究(In Vitro)	Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC50s in the range of 10 to 100 nM. Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	Ac-KPSSPPEE-NH2
Sequence	Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2
参考文献	[1]. Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 20 [2]. Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30.

溶解度数据	In Vitro: DMSO : 100 mg/mL (109.77 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (109.77 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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