Amodiaquine dihydrochloride|69-44-3|(Amodiaquin dihydrochloride)-陌孚医药/Medlife

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Amodiaquine dihydrochloride (Synonyms: Amodiaquin dihydrochloride)

目录号: PL08872 纯度: ≥99%

CAS No. :69-44-3

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中文名称	Amodiaquine dihydrochloride
中文别名	盐酸阿莫地喹;阿莫地喹盐酸盐;7-氯-4-(3'-二乙基氨基甲基-4'-羟基苯胺基)喹啉二盐酸盐;盐酸阿莫他喹;阿莫地喹碱;盐酸阿莫地喹，医药级,纯度:>99%;阿莫地喹二盐酸盐
英文名称	Amodiaquine dihydrochloride
英文别名	4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol dihydrochloride;4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)-methyl)phenol dihydrochloride;Acrichin dihydrochloride;AMODIAQUINE HYDROCHLORIDE,USP28;AMODIAQUIN DIHYDROCHLORIDE;AMODIAQUIN HYDROCHLORIDE;AMODIAQUINE DIHYDROCHLORIDE;AMODIAQUINE HCL;AMODIAQUINE HYDROCHLORIDE;camoquinhydrochloride;7-Chloro-4-(3'-diethylaminomethyl-4'-hydroxyanilino)quinoline dihydrochloride;4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride;Camoquin Hcl;Amodiaquine hydrochloride anhydrous;HOE64181MP;AK115177;4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol dihydrochloride;4-(7-Chloro-4-quinolylamino)-alpha-(diethylamino;4-((7-CHLOROQUINOLIN-4-YL)AMINO)-2-((DIETHYLAMINO)-METHYL)PHENOL 2HCL;CS-0013341;SB73131;o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-, dihydrochloride;4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol dihydrochloride;amodiaquinhydrochlorid-;Amodiaquine 2HCl;Acrichin dihydrochloride;Amodiaquine HCl;4-(7-Chloro-4-quinolylamino)-alpha-(diethylamino)-o-cresol dihydrochloride;BCP34401;Amodiaquin dihydrochloride;4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride;FT-0650478;EINECS 200-706-0;s5500;Amodiaquine hydrochloride;KSC-280-058;Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-, dihydrochloride;CAMOQUIN HYDROCHLORIDE;MFCD00078857;LS-55354;AMODIAQUINE DIHYDROCHLORIDE ANHYDROUS;AI3-52838;4-((7-CHLORO-4-QUINOLYL)AMINO)-.ALPHA.-(DIETHYLAMINO)-O-CRESOL DIHYDROCHLORIDE;AMODIAQUINE DIHYDROCHLORIDE, ANHYDROUS;AC-15935;2-[[bis(1,1,2,2,2-pentadeuterioethyl)amino]methyl]-4-[(7-chloroquinolin-4-yl)amino]phenol;dihydrochl;C20H22ClN3O.2ClH;W-104623;UNII-HOE64181MP;DTXSID20219036;4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;dihydrochloride;AKOS015962122;4-(7-chloroquinolin-4-ylamino)-2-((diethylamino)methyl)phenol dihydrochloride;KUC110919C;Amodiaquine (dihydrochloride);Acrichindihydrochloride;F16487;C20H22ClN3O.3HCl;SCHEMBL317888;AMODIAQUINEDIHYDROCHLORIDE;69-44-3;4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol dihydrochloride;CHEMBL3137745;CCG-268988;2-[[bis(1,1,2,2,2-pentadeuterioethyl)amino]methyl]-4-[(7-chloroquinolin-4-yl)amino]phenol;dihydrochloride;HY-B1322B;Ampdiaquine Hydrochloride (anhydrous);O-CRESOL, 4-((7-CHLORO-4-QUINOLYL)AMINO)-.ALPHA.-(DIETHYLAMINO)-, DIHYDROCHLORIDE ANHYDROUS;DS-4067;Q27280034;Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, dihydrochloride;Amodiaquine dihydrochloride
Cas No.	69-44-3
分子式	C₂₀H₂₄Cl₃N₃O
分子量	428.78
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Amodiaquine dihydrochloride (Amodiaquin dihydrochloride) 是一种4-氨基喹啉类抗疟剂，是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂，K_i 值为 18.6 nM。Amodiaquine dihydrochloride 也是一种 Nurr1 激动剂，可特异性结合 Nurr1 的配体结合域，EC₅₀ 为 ~20 μM。抗炎作用。

生物活性

Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a K i of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC 50 of ~20 μM. Anti-inflammatory effect.

性状

Solid

IC50 & Target[1][2]

EC50: ~20 μM (Nurr1-LBD (ligand binding domain))
Histamine N-methyltransferase

体外研究(In Vitro)

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinsons disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61.
[2]. Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54.

溶解度数据	In Vitro: DMSO : 125 mg/mL (291.52 mM; Need ultrasonic)H₂O : 50 mg/mL (116.61 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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