GW791343 dihydrochloride|1019779-04-4|-陌孚医药/Medlife

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GW791343 dihydrochloride

目录号: PL08668 纯度: ≥98%

CAS No. :1019779-04-4

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中文名称	GW791343 dihydrochloride
中文别名	2-[(3,4-二氟苯基)氨基]-N-[2-甲基-5-(1-哌嗪基甲基)苯基]乙酰胺盐酸盐;GW791343(盐酸盐)
英文名称	GW791343 dihydrochloride
英文别名	GW791343 (HCL);GW 791343 hydrochloride;GW 791343 hydrochloride,2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride;GW 791343 Trihydrochloride;GW791343 dihydrochloride;GW-791343 dihydrochloride;2-[(3,4-DIFLUOROPHENYL)AMINO]-N-[2-METHYL-5-(PIPERAZIN-1-YLMETHYL)PHENYL]ACETAMIDE;2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]acetamide hydrochloride;GW 791343;GW791343 (dihydrochloride);2-((3,4-difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride;2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride
Cas No.	1019779-04-4
分子式	C₂₀H₂₄N₄OF₂^.HCl
分子量	410.89
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	GW791343 dihydrochloride 是一种有效的人 P2X7 受体负变构调节剂 (有种属特异性)，对人 P2X7 受体产生非竞争性拮抗作用，其 pIC₅₀ 值为 6.9-7.2。GW791343 dihydrochloride 能增强昼夜交替的 ATP 释放。GW791343 dihydrochloride 可用于神经系统疾病的研究。
生物活性	GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC 50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease.
性状	Solid
IC50 & Target[1][2]	P2X7 Receptor 6.9-7.2 (pIC50)
体外研究(In Vitro)	GW791343 dihydrochloride (0.01, 0.03, 0.1, 0.3, 1, 3, 10 μM; 40 min) shows a non-competitive antagonistic activity to the human P2X7 receptor. GW791343 dihydrochloride (3, 10, 30 μM; 40 min) shows an anegative allosteric modulate activity to the human P2X7 receptor. GW791343 dihydrochloride (5 μM; 24-48 h; ATP measured every 4 h) enhances ATP rhythm in SCN cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Michel AD, et al. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol. 2008 Feb;153(4):737-50. [2]. Svobodova I, et al. Circadian ATP Release in Organotypic Cultures of the Rat Suprachiasmatic Nucleus Is Dependent on P2X7 and P2Y Receptors. Front Pharmacol. 2018 Mar 6;9:192.

溶解度数据	In Vitro: H₂O : 100 mg/mL (223.54 mM; Need ultrasonic)DMSO : 20 mg/mL (44.71 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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