Netropsin dihydrochloride|18133-22-7|(纺锤菌素二盐酸；纺锤菌素)-陌孚医药/Medlife

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Netropsin dihydrochloride (Synonyms: 纺锤菌素二盐酸；纺锤菌素)

目录号: PL08116 纯度: ≥99%

CAS No. :18133-22-7

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中文名称	Netropsin dihydrochloride
中文别名	水合纺锤菌素氟安定;纺锤菌素二盐酸;纺锤菌素
英文名称	Netropsin dihydrochloride
英文别名	1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-1-methyl-,hydrochloride (1:2);1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminop...;1H-Pyrrole-2-carboxamide,4-[[2-[(aminoiminomethyl)amino]acetyl]amino]-N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-;N-[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(diaminomethylideneamino)acetyl]amino]-1-methylpyrrole-2-carboxamide,hydrochloride;4-{4-[(N-Carbamimidoyl-glycyl)-amino]-1-methyl-pyrrol-2-carbonylamino}-1-methyl-pyrrol-2-carbonsaeure-(2-carbamimidoyl-aethylamid), Dihydrochlorid;4-{4-[(N-carbamimidoyl-glycyl)-amino]-1-methyl-pyrrole-2-carbonylamino}-1-methyl-pyrrole-2-carboxylic acid-(2-carbamimidoyl-ethylamide), dihydrochloride;AC1NS0LC;ANTIBIOTIC 1A-887;CHEMBL553984;congocidin dihydroch;DNC001009;LA 887;NETROPSIN CHLORIDE;Netropsin dihydrochloride
Cas No.	18133-22-7
分子式	C₁₈H₂₆N₁₀O₃^.HCl
分子量	466.93
包装储存	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Netropsin dihydrochloride 是一种小分子(MGB) 小沟结合剂，抑制分离的拓扑异构酶的催化活性，并干扰拓扑异构酶 II 和 I 在细胞核中的可降解复合物的稳定性。Netropsin dihydrochloride 对牛痘病毒具有抗病毒活性。
生物活性	Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus.
性状	Solid
体外研究(In Vitro)	Netropsin dihydrochloride has potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner, it improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter. Netropsin dihydrochloride in solutions of DNA has radioprotective ability against radiation-induced damage due to its high binding affinity and high structural stabilization, hydroxyl radical (OH*) generated by ionizing radiation cannot radiolyse the netropsin-DNA complex. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60. [2]. Grant MA, et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15;418(1):103-12.

溶解度数据	In Vitro: DMSO : 125 mg/mL (248.32 mM; Need ultrasonic)H₂O : 20 mg/mL (39.73 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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