Orexin B, rat, mouse TFA||(Rat orexin B TFA; Orexin B (mouse) (TFA))-陌孚医药/Medlife

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Orexin B, rat, mouse TFA (Synonyms: Rat orexin B TFA; Orexin B (mouse) (TFA))

目录号: PL08106 纯度: ≥98%

商品编号	规格	价格	会员价
PL08106-1mg	1mg	¥3709.09	请登录
PL08106-5mg	5mg	¥9272.73	请登录
PL08106-10mg	10mg	询价	询价
PL08106-50mg	50mg	询价	询价

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中文名称	Orexin B, rat, mouse TFA
英文名称	Orexin B, rat, mouse TFA
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Orexin B, rat, mouse (Rat orexin B) TFA 是一种内源性增食欲素受体 (Orexin receptor) 激动剂。Orexin B, rat, mouse TFA 结合并激活两个密切相关的孤儿 G 蛋白偶联受体 OX1-R 和 OX2-R。Orexin B, rat, mouse TFA 刺激食物摄入和能量消耗，并在睡眠-觉醒调节中发挥重要作用。
生物活性	Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.
性状	Solid
体外研究(In Vitro)	OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2
参考文献	[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [3]. Ziolkowska A, et al. Orexin

溶解度数据	In Vitro: H₂O : 100 mg/mL (32.78 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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