6-Azathymine|932-53-6|-陌孚医药/Medlife

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6-Azathymine

目录号: PL07998 纯度: ≥99%

CAS No. :932-53-6

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中文名称	6-Azathymine
中文别名	6-氮杂胸腺嘧啶;6-Azathymine 6-氮杂胸腺嘧啶;6-甲基-1,2,4-三嗪-3,5(2H,4H)-二酮;硬脂酸钠;6-吖胸嘧啶;6-氮胸嘧啶
英文名称	6-Azathymine
英文别名	6-methyl-1,2,4-triazine-3,5-diol;6-Azathymine;6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione;6-methyl-2H-1,2,4-triazine-3,5-dione;1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl;5-Methyl-6-azauracil;6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione;6-Methyl-2H-[1,2,4]triazin-3,5-dion;6-methyl-2H-[1,2,4]triazin-3,5-dione;6-methyl-2H-[1,2,4]triazine-3,5-dione;Azathymine;Azathymine,6;USAF CB-28;1,2,4-Triazine-3,5(2H,4H)-dione, 6-methyl-;6-Methyl-1,2,4-triazine-3,5-dione;Azathymine, 6;6-Methyl-as-triazine-3,5-(2H,4H)-dione;3,5-Dihydroxy-6-methyl-1,2,4-triazine;6-Methyl-as-triazine-3,5-diol;as-Triazine-3,5(2H,4H)-dione, 6-methyl-;ZWX58T58ZA;XZ
Cas No.	932-53-6
分子式	C₄H₅N₃O₂
分子量	127.10
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	6-Azathymine，胸腺嘧啶的 6-氮类似物，是一种有效的 D-3-氨基异丁酸酯-丙酮酸氨基转移酶 (D-3-aminoisobutyrate-pyruvate aminotransferase) 抑制剂。6-Azathymine 可抑制 DNA 的生物合成，并具有抗菌和抗病毒活性。
生物活性	6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities.
性状	Solid
体外研究(In Vitro)	6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. [2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14.

溶解度数据	In Vitro: DMSO : 125 mg/mL (983.48 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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