Trifluridine|70-00-8|(曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT)-陌孚医药/Medlife

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Trifluridine (Synonyms: 曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT)

目录号: PL07970 纯度: ≥99%

CAS No. :70-00-8

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中文名称	Trifluridine
中文别名	三氟尿苷;曲氟尿苷;三氟甲苷;三氟胸苷;三氟甲尿苷;三氟哩啶;三氟胸腺嘧啶核苷;5-三氟甲-2-脱氧尿苷;三氟尿苷 GMP;曲氟胸苷;Trifluorothymidine 曲氟胸苷;曲氟胸苷 USP标准品;三氟胸B51003苷;曲氟胸甙;三氟甲基尿嘧啶去氧核苷;三氟胸苷杂质
英文名称	Trifluridine
英文别名	1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione;2-Deoxy-5-(trifluoromethyl)uridine;5-(Trifluoromethyl)-2-deoxyuridine;trifluridine;alpha,alpha,alpha-Trifluorothymidine;Trifluorothymidine;2'-Deoxy-5-(trifluoromethyl)uridine;5-Trifluorothymidine;MAGNESIUM HYDROXIDE, NANOMETER GRADE;FTD;NSC 529182;NSC 75520;α,α,α-Trifluorothymidine;2′-Deoxy-5-trifluoromethyluridine;Trifluorothymine deoxyriboside;2'-Deoxy-5-trifluoromethyluridine;5-(Trifluoromethyl)-2'-deoxyuridine;三氟胸苷;Trifluridine impuritu;Viroptic;Trifluridina;Trifluoromethyldeoxyuridine;Trifluridinum;Virophta;F3TDR;F3DThd;TFDU;5-(Trifluoromethyl)deoxyuridine;5-Trifluoromethyl-2-deoxyuridine;Fluridine;Trifluridinum [INN-Latin];Trifluridina [INN-Spanish];Trifluridine [USAN:INN];5-Trifluoro-2'-deoxythymidine;2'-Deoxy-5-trifluoro;TRIFLUOROTHYMIDINE;D05RHI;CCG-221056;Trifluridine (Viroptic);BRN 0568095;T2511;Q2359590;CAS-70-00-8;TRIFLURIDINE [USAN];cid_6256;Opera_ID_1810;5-trifluoromethyl-2''-deoxyuridine;C10-H11-F3-N2-O5;Trifluridine (USP/INN);C10H11F3N2O5;Trifluridine;FTD;5-Trifluorothymidine;NSC 529182;NSC 75520;RMW9V5RW38;CHEBI:75179;Trifluridine, British Pharmacopoeia (BP) Reference Standard;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;TRIFLURIDINE [INN];S-95005 COMPONENT TRIFLURIDINE;Trifluoromethyl Deoxyuridine;D00391;TAS-102 COMPONENT TRIFLURIDINE;Trifluridine, United States Pharmacopeia (USP) Reference Standard;SMR000058583;CS-1602;Tox21_112411;Trifluridine (JAN/USP/INN);J-700357;Tox21_112411_1;HSDB 8126;TRIFLURIDINE [USP-RS];AKOS015919482;MLS006010219;Trifluorothymidine, >=99% (HPLC);Viroptic (TN);NCGC00166323-02;5-Trifluoromethyl-2'-deoxyuridine;F3T;Trifluridine [USAN:USP:INN];DTXCID2026602;CHEMBL1129;trifluridin-;DB00432;SR-01000721911-2;HS-0007;70-00-8;TRIFLURIDINE [JAN];1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione;Uridine, 2'-deoxy-5-(trifluoromethyl)-;EINECS 200-722-8;S1778;DRG-0120;NCGC00166323-01;NSC-75520;SCHEMBL3479;CF3dUrd;MFCD00006534;Viroptic, Trifluorothymidine, Trifluridine;1-((2R,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-trifluoromethyl-1H-pyrimidine-2,4-dione;TRIFLURIDINE [USP MONOGRAPH];Thymidine, .alpha.,.alpha.,.alpha.-trifluoro-;BRD-K03243820-001-12-1;Trifluridine;HMS2233N19;BRD-K03243820-001-25-3;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-(trifluoromethyl)-;BCP09147;BDBM50132298;NCGC00166323-16;LS-153788;NSC-529182;AM20100660;TRIFLURIDINE [MART.];Trifluoridine;A836733;NSC529182;Thymidine, alpha,alpha,alpha-trifluoro-;HMS3715C14;J-700255;NSC75520;BP-58659;SRI-10817_14;TRIFLURIDINE [WHO-DD];DTXSID4046602;SW199522-2;TRIFLURIDINE [ORANGE BOOK];CCRIS 2348;1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-...
Cas No.	70-00-8
分子式	C₁₀H₁₁F₃N₂O₅
分子量	296.20
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) 是不可逆的胸苷酸合酶抑制剂，从而抑制 DNA合成。Trifluridine 是用于单纯疱疹病毒 (HSV) 感染的抗病毒药物。Trifluorothymidine 还具有抗正痘病毒 (orthopoxvirus) 活性。

生物活性

Trifluridine (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity.

性状

Solid

IC50 & Target[1][2]

Thymidylate Synthase Nucleoside Antimetabolite/Analog

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70.
[2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397.
[3]. Temmink

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (337.61 mM)H₂O : 33.33 mg/mL (112.53 mM; ultrasonic and warming and heat to 60°C)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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