3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) 是一种核苷酸类似物，可抑制 DNA 依赖性 RNA 聚合酶 I 和 II (RNA polymerases I 和 II)，强烈并竞争性地抑制 UTP 掺入到 RNA 中，K_i 值为 2.0 μM。

3-Deoxyuridine-5-triphosphate trisodium (3-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3-Deoxyuridine-5-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a K i value of 2.0 μM.

Solid

3-Deoxyuridine-5-triphosphate (3-dUTP) is synthesized starting from cordycepin in good yield. 3-Deoxyuridine-5-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3-Deoxyuridine-5-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

[1]. M Saneyoshi, et al. Inhibitory Effects of 3deoxycytidine 5-triphosphate and 3-deoxyuridine 5-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.

In Vitro: H₂O : 20 mg/mL (37.45 mM; Need ultrasonic)配制储备液