S-Nitroso-N-acetyl-DL-penicillamine|67776-06-1|(SNAP)-陌孚医药/Medlife

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S-Nitroso-N-acetyl-DL-penicillamine (Synonyms: SNAP)

目录号: PL07844 纯度: ≥98%

CAS No. :67776-06-1

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中文名称	S-Nitroso-N-acetyl-DL-penicillamine
中文别名	S-亚硝基-N-乙酰基-DL-青霉胺;N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸;S-亚硝基-N-乙酰-DL-青霉胺;S-亚硝基N-乙酰基-DL-青霉胺
英文名称	S-Nitroso-N-acetyl-DL-penicillamine
英文别名	Valine,N-acetyl-3-(nitrosothio)-;S-Nitroso-N-acetyl-D,L-penicillamine;SNAP [S-Nitroso-N-acetylpenicillamine];SNAP;N-Acetyl-3-(nitrosothio)-DL-valine;S-Nitroso-N-acetylpenicillamine;SNAP (amino acid);S-Nitroso-N-acetyl-DL-penicillamine;Valine, N-acetyl-3-(nitrosothio)-;2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid;S-Nonap;SNAP (S-NITROSO-N-ACETYLPENICILLAMINE);N-Acetyl-S-nitroso-DL-penicillamine;N-(Acetyloxy)-3-(nitrosothio)valine;(+/-)-S-Nitroso-N-acetylpenicillamine;DL-Valine, N-acetyl-3-(nitrosothio)-;NSC312630;N-Acetyl-S-nitrosopeni
Cas No.	67776-06-1
分子式	C₇H₁₂N₂O₄S
分子量	220.25
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种一氧化氮供体，是一种稳定的血小板聚集抑制剂。

生物活性

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation.

性状

Solid

体外研究(In Vitro)

S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO).
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes.
S-Nitroso-N-acetyl-DL-penicillamine (100 μM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [H]-acetylcholine release in guinea-pig tracheal.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. E. Salas, et al. Comparative pharmacology of analogues of S-nitroso-N-acetyl-DL-penicillamine on human platelets. Br J Pharmacol. 1994 Aug;112(4):1071-6.
[2]. Ioannidis I, et al. Enhanced release of nitric oxide causes increased cytotoxicity of S-nitroso-N-acetyl-DL-penicillamine and sodium nitroprusside under hypoxic conditions. Biochem J. 1996 Sep 15;318 ( Pt 3):789-95.

溶解度数据	In Vitro: DMSO : 250 mg/mL (1135.07 mM; Need ultrasonic)H₂O : 11.11 mg/mL (50.44 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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