Muramyl dipeptide|53678-77-6|(MDP)-陌孚医药/Medlife

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Muramyl dipeptide (Synonyms: MDP)

目录号: PL07859 纯度: ≥98.0%

CAS No. :53678-77-6

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中文名称	Muramyl dipeptide
中文别名	N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺水合物;胞壁酰二肽;佐剂肽;N-乙酰胞壁酰-L-丙-D-异谷氨酰胺水合物
英文名称	Muramyl dipeptide
英文别名	D-a-Glutamine,N-(N-acetylmuramoyl)-L-alanyl-;Ac-muramyl-Ala-D-Glu-NH?;Ac-muramyl-Ala-D-Glu-NH₂;Ac-muramyl-Ala-D-Isogln-OH, MDP, Muramyl Dipeptide;ADJUVANT PEPTIDE;N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE;: N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE;AC-MURAMYL-ALA-D-GLN;AC-MURAMYL-ALA-D-ISOGLN-OH;Adjuvant Peptide,Muramyl dipeptide;L-18-MDP;MDP;N-AC-MURAMYL-ALA-D-GLU-NH2;Nod2 ligand muramyl dipeptide;Muramyl dipeptide;Adjuvant Peptide
Cas No.	53678-77-6
分子式	C₁₉H₃₂N₄O₁₁
分子量	492.48
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

Muramyl dipeptide (MDP)，是一种合成的免疫反应肽 (immunoreactive peptide)，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。Muramyl dipeptide 是通过 Runx2 诱导骨形成的诱导因子。Muramyl dipeptide 通过 MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。Muramyl dipeptide 是 NLRP1 激动剂。

生物活性

Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist.

性状

Solid

IC50 & Target[1][2]

p38 MAPK NLRP1

体外研究(In Vitro)

Muramyl dipeptide (0.1-10 μg/mL; 24 hours) increases protein expression of Runx2 in a dose-dependent manner.
Muramyl dipeptide (0.1-10 μg/mL; 6 hours) increases mRNA levels of Runx2 in a dose-dependent manner.
Muramyl dipeptide indirectly attenuates osteoclast differentiation through a decreased RANKL/OPG ratio.
has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

Muramyl dipeptide (1.25 mg/kg; i.p.; twice) alleviates bone loss induced by osteoporosis. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: RANKL-induced osteoporosis model (Five-week-o

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Park OJ, et al. Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2. J Bone Miner Res. 2017 Jul;32(7):1455-1468.
[2]. V Kaushal, et al. Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation. Cell Death Differ. 2015 Oct;22(10):1676-86.

溶解度数据	In Vitro: DMSO : 260 mg/mL (527.94 mM; Need ultrasonic)H₂O : 50 mg/mL (101.53 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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